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Original Investigation |

Changing Incidence Trends of Cutaneous T-Cell Lymphoma

Kaveri Korgavkar, BS1,2; Michael Xiong, BS1,2; Martin Weinstock, MD, PhD1,2,3,4
[+] Author Affiliations
1Department of Dermatology, Brown University, Providence, Rhode Island
2Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, Rhode Island
3Department of Epidemiology, Brown University, Providence, Rhode Island
4Department of Dermatology, Rhode Island Hospital, Providence
JAMA Dermatol. 2013;149(11):1295-1299. doi:10.1001/jamadermatol.2013.5526.
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Importance  Cutaneous T-cell lymphoma (CTCL) incidence and survival have been increasing steadily for over 25 years.

Objective  We sought to measure changes in CTCL incidence trends and survival rates.

Design, Setting, and Participants  Population-based study. The CTCL incidence and survival data were obtained from the 9 original registries (1973-2009) and the 4 additional registries (1992-2009) of the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute (NCI). Trend analysis was performed using the Joinpoint Regression Program provided by the NCI. Survival analysis was performed using the SeerSTAT statistical software of the NCI. The total number of cases of CTCL from 1973 to 2009 was 6230.

Main Outcomes and Measures  Diagnoses of CTCL.

Results  Overall CTCL incidence has stabilized since 1998 (95% CI, 1994-2002), with an annual percent change (APC) of 5.7% from 1973 to 1998 (95% CI, 4.9%-6.5%) and an APC of 0.1% from 1998 to 2009 (95% CI, −1.4% to 1.5%). Similar incidence stabilization patterns were found in subgroup analyses of race, sex, age, diagnosis, and registry. Five-year CTCL survival rates increased until 2004.

Conclusions and Relevance  The incidence of CTCL is no longer increasing. Causes for this trend change may include real incidence stabilization, stabilization of physician detection, or artifact.

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Overall CTCL Incidence Between 1973 and 2009 From 9 Surveillance, Epidemiology, and End Results Registries,3 Including Original Data Points and Incidence Trends
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