Observation |

Vemurafenib-Induced DRESS

Kurt S. Wenk, MD1; Dominique C. Pichard, MD1; Teresa Nasabzadeh, MD1; Sekwon Jang, MD2; Suraj S. Venna, MD2
[+] Author Affiliations
1Department of Dermatology, Georgetown University Hospital/Washington Hospital Center, Washington, DC
2Medstar Melanoma Center at the Washington Cancer Institute, Washington, DC
JAMA Dermatol. 2013;149(10):1242-1243. doi:10.1001/jamadermatol.2013.5278.
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The BRAF inhibitor vemurafenib was approved by the US Food and Drug Administration in 2011 for the treatment of metastatic melanoma in individuals harboring the somatic BRAF V600E mutation. Cutaneous adverse events from vemurafenib are frequent and include skin eruption, pruritus, photosensitivity, hyperkeratosis, squamous cell carcinoma, and keratoacanthomas.1,2 We report herein a case of vemurafenib-induced drug reaction with eosinophilia and systemic symptoms (DRESS).

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Vemurafenib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms

Diffuse eruption affecting the back 3 weeks after starting vemurafenib therapy.

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