Case Report/Case Series | The cutting Edge

Successful Treatment of Severe Hidradenitis Suppurativa With Anakinra

Kian Zarchi, MD1; Deirdre Nathalie Dufour, MD1; Gregor B. E. Jemec, MD, DMSc1
[+] Author Affiliations
1Department of Dermatology, Roskilde Hospital, Health Science Faculty, University of Copenhagen, Roskilde, Denmark
JAMA Dermatol. 2013;149(10):1192-1194. doi:10.1001/jamadermatol.2013.5377.
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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that is characterized by painful and suppurating lesions. Herein, we report a case of severe HS that was refractory to multiple treatments but responded rapidly to anakinra injections.

Section Editor: Edward W. Cowen, MD, MHSc; Assistant Section Editors: Murad Alam, MD; Ruth Ann Vleugels, MD

Article Information

Accepted for Publication: May 12, 2013.

Corresponding Author: Kian Zarchi, MD, Department of Dermatology, Roskilde Hospital, Koegevej 7-13, 4000, Roskilde, Denmark (kian_zarchi@yahoo.com)

Published Online: August 21, 2013. doi:10.1001/jamadermatol.2013.5377.

Author Contributions: Study concept and design: All authors.

Acquisition of data: All authors.

Analysis and interpretation of data: Zarchi, Jemec.

Drafting of the manuscript: Zarchi, Dufour.

Critical revision of the manuscript for important intellectual content: Dufour, Jemec.

Obtained funding: Jemec.

Administrative, technical, and material support: Dufour, Jemec.

Study supervision: Jemec.

Conflict of Interest Disclosure: None reported.

Additional Contributions: We thank the patient who made this report possible.

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Figure 1.
Pubic and Inguinal Regions Before the Initial Administration of Anakinra

Draining sinuses, inflammatory nodules, and hypertrophic scar indicating severe hidradenitis suppurativa.

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Figure 2.
Pubic and Inguinal Regions After 1 Year of Anakinra Treatment

Decreased erythema and drainage and resolution of inflammatory nodules showing a marked improvement.

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