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Paraneoplastic Autoimmune Multiorgan Syndrome in a Patient With Li Fraumeni Syndrome

Susan Margaret O'Gorman, MB BCh BAO1; Rochelle Torgerson, MD, PhD, FAAD2
[+] Author Affiliations
1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota
2Division of Clinical Dermatology, Mayo Clinic, Rochester, Minnesota
JAMA Dermatol. 2013;149(9):1116-1117. doi:10.1001/jamadermatol.2013.4982.
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Treatment of paraneoplastic autoimmune multiorgan syndrome (PAMS) can be challenging; a p53 tumor suppressor mutation adds a further layer of complexity.

Article InformationCorresponding Author: Susan Margaret O'Gorman, MB BCh BAO, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (susanmogorman@gmail.com).

Published Online: July 31, 2013. doi:10.1001/jamadermatol.2013.4982.

Conflict of Interest Disclosures: None reported.

Additional Contributions: We are indebted to Alina G. Bridges, DO, for her help with histopathological findings in this case.

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Photographic Images From the Subject Case

A, Severe mucosal ulceration at initial presentation. B, Lichenoid mucositis, left buccal mucosa, bandlike lymphocytic inflammation at the mucosal-submucosal junction, basal vacuolar degeneration, and pigment incontinence (hematoxylin-eosin, original magnification ×20).

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