0
Observation |

Intralesional Cidofovir for Treating Extensive Genital Verrucous Herpes Simplex Virus Infection

Karolyn A. Wanat, MD1; Rachel H. Gormley, MD1; Misha Rosenbach, MD1; Carrie L Kovarik, MD1
[+] Author Affiliations
1Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia
JAMA Dermatol. 2013;149(7):881-883. doi:10.1001/jamadermatol.2013.4014.
Text Size: A A A
Published online

Extract

Verrucous herpes simplex viral infections in immunocompromised patients can be a therapeutic challenge, and we present a case of successful treatment with intralesional cidofovir.

Article InformationCorresponding Author: Carrie L. Kovarik, MD; Department of Dermatology, University of Pennsylvania, 3600 Spruce St, Philadelphia, PA 19104 (carrie.kovarik@uphs.upenn.edu).

Conflict of Interest Disclosure: None reported.

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure 1.
Verrucous Herpes Simplex Virus Before (A and B) and After (C and D) Treatment

Exophytic, verrucous, and ulcerated plaques were found on his right inferior scrotum (A) and perianal area (B). After 6 treatments with intralesional cidofovir, there was resolution of the plaques on the scrotum (C) and near complete resolution in the perianal area (D).

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Histopathologic Images

A, Acanthotic epidermis at the edge of an ulceration with acute inflammation (hematoxylin-eosin, original magnification ×100) with prominent multinucleated giant cells (B and C, hematoxylin-eosin, original magnification ×200 and ×400, respectively). D, Herpes viral infection was confirmed with positive immunoperoxidase staining of multinucleated giant cells (herpes simplex virus immunohistochemical staining, original magnification ×200).

Graphic Jump Location

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
Jobs
brightcove.createExperiences();