Observation |

Intralesional Cidofovir for Treating Extensive Genital Verrucous Herpes Simplex Virus Infection

Karolyn A. Wanat, MD1; Rachel H. Gormley, MD1; Misha Rosenbach, MD1; Carrie L Kovarik, MD1
[+] Author Affiliations
1Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia
JAMA Dermatol. 2013;149(7):881-883. doi:10.1001/jamadermatol.2013.4014.
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Verrucous herpes simplex viral infections in immunocompromised patients can be a therapeutic challenge, and we present a case of successful treatment with intralesional cidofovir.

Article InformationCorresponding Author: Carrie L. Kovarik, MD; Department of Dermatology, University of Pennsylvania, 3600 Spruce St, Philadelphia, PA 19104 (carrie.kovarik@uphs.upenn.edu).

Conflict of Interest Disclosure: None reported.

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Figure 1.
Verrucous Herpes Simplex Virus Before (A and B) and After (C and D) Treatment

Exophytic, verrucous, and ulcerated plaques were found on his right inferior scrotum (A) and perianal area (B). After 6 treatments with intralesional cidofovir, there was resolution of the plaques on the scrotum (C) and near complete resolution in the perianal area (D).

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Figure 2.
Histopathologic Images

A, Acanthotic epidermis at the edge of an ulceration with acute inflammation (hematoxylin-eosin, original magnification ×100) with prominent multinucleated giant cells (B and C, hematoxylin-eosin, original magnification ×200 and ×400, respectively). D, Herpes viral infection was confirmed with positive immunoperoxidase staining of multinucleated giant cells (herpes simplex virus immunohistochemical staining, original magnification ×200).

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