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Invited Commentary | Practice Gaps

Drug-Induced Subacute Cutaneous Lupus Erythematosus—Filling the Gap in Knowledge Comment on “Subacute Cutaneous Lupus Erythematosus Induced by Chemotherapy”

Jeffrey P. Callen, MD1
[+] Author Affiliations
1Division of Dermatology, Department of Medicine, University of Louisville, Louisville, Kentucky
JAMA Dermatol. 2013;149(9):1075-1076. doi:10.1001/jamadermatol.2013.4958.
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The year 1979 marked the first publication that used the term subacute cutaneous lupus erythematosus (SCLE).1 Six years later, in 1985, Reed et al2 first linked a drug to the onset of the disease, namely, hydrochlorothiazide. During almost 3 decades since that publication, multiple drugs have been linked to this phenomenon, now numbering more than 100 agents, and the occurrence of a drug as a cause or as an exacerbating agent represents roughly 20% of newly diagnosed cases of SCLE.3

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