Invited Commentary | Practice Gaps

Underrecognition of the Heterogeneous Clinical Spectrum of Bullous Pemphigoid

Michael Hertl, MD1; Thomas Schmidt, PhD1
[+] Author Affiliations
1Departments of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany
JAMA Dermatol. 2013;149(8):954-955. doi:10.1001/jamadermatol.2013.4250.
Text Size: A A A
Published online


Bullous pemphigoid (BP) is commonly characterized clinically by the presence of tense blisters that develop on erythematous or urticarial pruritic skin. To establish the diagnosis of BP, the presence of tissue-bound IgG autoantibodies against components of the dermoepidermal basement membrane (by direct immunofluorescence of perilesional skin) and of serum IgG autoantibodies (by indirect immunofluorescence or enzyme-linked immunosorbent assay [ELISA]) is mandatory according to newly published guidelines.1 Recently, it has become apparent that the clinical spectrum of BP is rather heterogeneous.1,2 Several atypical, nonbullous clinical variants have been acknowledged that have urticarial or erythematous plaques, eczema-like or prurigo-like lesions with pruritic papules or nodules, generalized multiforme-like exanthems, and pruritus sine materia. A common feature of all clinical pemphigoid variants is a pronounced pruritus, which recently has been included as a diagnostic criterion of pemphigoid.3

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Topics
PubMed Articles