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Research Letters |

Oral Minocycline in Treatment of Cutaneous Sarcoidosis

Talora Steen, BS; Joseph C. English, MD
JAMA Dermatol. 2013;149(6):758-760. doi:10.1001/jamadermatol.2013.2977.
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Currently, therapeutic techniques used to treat cutaneous sarcoidosis rely on limited data from evidenced-based research.1,2 Bachelez et al3 conducted a prospective study in which 10 of 12 patients showed improvement after minocycline therapy, and Antonovich and Callen4 reported the case of 1 woman who was successfully treated with doxycycline. On the basis of these encouraging reports, our clinic began to use minocycline, a commonly used anti-inflammatory acne therapy that does not require laboratory monitoring, as a first-line treatment for cutaneous sarcoidosis. The present retrospective study sought to evaluate our experience with minocycline treatment and to compare its effectiveness across sex and race.

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Figure 1. Outcomes of minocycline therapy in the present study (P = .02). CR indicates complete remission; NR, no remission; PR, partial remission.

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Figure 2. Pretreatment (A) and posttreatment (B) views of a patient with cutaneous sarcoidosis with minocycline.

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