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Implications for Biologic Therapy: Staphylococcus aureus Decolonization of Individuals With a History of Recurrent Skin and Soft-Tissue Infections

Jennifer H. Ku, MPH1; Kevin L. Winthrop, MD, MPH1,3,4; Cara D. Varley, MPH1; Annika Sullivan, BA1; Benjamin D. Ehst, MD, PhD2; Andrew Blauvelt, MD2; Atul A. Deodhar, MD3,5
[+] Author Affiliations
1Department of Ophthalmology, Oregon Health and Science University, Portland
2Department of Dermatology, Oregon Health and Science University, Portland
3Department of Medicine, Oregon Health and Science University, Portland
4Division of Infectious Diseases, Oregon Health and Science University, Portland
5Division of Arthritis and Rheumatic Disease, Oregon Health and Science University, Portland
JAMA Dermatol. 2013;149(8):986-989. doi:10.1001/jamadermatol.2013.4405.
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Patients with immune-mediated inflammatory diseases (IMIDs) are at an increased risk for skin and soft-tissue infections (SSTIs),1 presumably owing to colonizing organisms like Staphylococcus aureus.1 Although few organism-level data are available by which to judge whether these agents increase the risk of S aureus infection specifically, biologic therapies widely used to treat IMIDs have been shown to increase the risk of SSTIs and other serious infections, complicating therapeutic management of IMIDs.2,3 Although staphylococcal decolonization therapy has been used in various health care settings, no description of such therapy exists for patients with IMIDs with recurrent SSTIs on biologic therapies. For those patients with recurrent infections thought to be due to S aureus, decolonization could theoretically provide protection against subsequent infection.

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