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Successful Treatment of Rosai-Dorfman Disease With Low-Dose Oral Thalidomide

Xiaodong Li, MD, PhD1,2; Yuxiao Hong, MD2; Qian An, MD2; John Chen, MD3; Huachen Wei, MD, PhD4; Hong-Duo Chen, MD2; Xing-Hua Gao, MD, PhD2
[+] Author Affiliations
1Fengtian Hospital Affiliated with Shenyang Medical College, Shenyang, China
2Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang
3Sheftel Associates Dermatology, Tucson, Arizona
4Department of Dermatology, Dermatology Research Laboratories, Mount Sinai Medical Center, New York, New York
JAMA Dermatol. 2013;149(8):992-993. doi:10.1001/jamadermatol.2013.4399.
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Rosai–Dorfman disease (RDD) is a rare idiopathic histiocytic proliferative disorder.1 The skin is the most frequently involved extranodal organ. Nevertheless, primary cutaneous manifestation of RDD (CRDD) without systemic involvement is rare.2 We present herein a case of CRDD showing excellent remission after low-dose oral thalidomide therapy.

Article InformationCorresponding Authors: Xing-Hua Gao, MD, PhD, and Hong-Duo Chen, MD, Department of Dermatology, No. 1 Hospital of China Medical University, 155 N Nanjing St, Shenyang 110001, People’s Republic of China (gaobarry@hotmail.com).

Published Online: June 19, 2013. doi:10.1001/jamadermatol.2013.4399.

Conflict of Interest Disclosures: None reported.

Funding/Support: This work was supported in part by the Program for Innovative Research Team in Universities, Liaoning Province (LT2012012), National Natural Science Foundation of China (30972659).

Role of the Sponsors: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions: Written informed consent was obtained from the patient for submission and publication of this case report and accompanying images.

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A, Erythematous plaques with reddish-yellow nodules on his face. B, After 8 months of thalidomide treatment, the nodules are nearly resolved, and most of erythematous plaques are lightened or even cleared.

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