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Research Letter |

A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral Polypodium leucotomos Extract as an Adjunct to Sunscreen in the Treatment of Melasma

Ammar M. Ahmed, MD1; Isha Lopez, MD1; Francisco Perese, BS1; Rebecca Vasquez, MD1; Linda S. Hynan, PhD1; Benjamin Chong, MD1; Amit G. Pandya, MD1
[+] Author Affiliations
1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas
JAMA Dermatol. 2013;149(8):981-983. doi:10.1001/jamadermatol.2013.4294.
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Extract

Treatments for melasma include photoprotection in conjunction with topical agents such as hydroquinone, retinoids, or combinations. These regimens, while reasonably effective, are hindered by adverse effects such as irritation and ochronosis.1,2 Aggressive topical sunscreen use improves melasma as monotherapy.3 However, compliance with frequent sunscreen application is difficult; a more convenient and effective photoprotective regimen is needed. We assessed the effectiveness of Polypodium leucotomos extract (PLE), an oral, commercially available UV radiation protectant, as an adjunct to once-daily topical sunscreen application in the treatment of melasma.

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Figure 1.
Mexameter (Courage and Khazaka Inc) Results

Improvement seen in both groups at weeks 6 and 12 but no significant intergroup difference. ANCOVA indicates analysis of covariance; ANOVA, analysis of variance; PLE, Polypodium leucotomos extract.

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Figure 2.
Melasma Area and Severity Index (MASI) Results

Improvement seen in both groups at weeks 6 and 12 but no significant intergroup difference. ANCOVA indicates analysis of covariance; PLE, Polypodium leucotomos extract.

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