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Correspondence |

Eruptive Melanocytic Nevi in a Patient Undergoing Treatment With Sunitinib

David Jiménez-Gallo, MD; Cristina Albarrán-Planelles, MD; Mario Linares-Barrios, PhD; Alberto Martínez-Rodríguez, PhD; José María Báez-Perea, PhD
JAMA Dermatol. 2013;149(5):624-626. doi:10.1001/jamadermatol.2013.263.
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The onset of eruptive melanocytic nevi (EMN) is an uncommon phenomenon characterized by sudden onset of multiple melanocytic nevi (MN). This phenomenon has been linked primarily to bullous diseases or conditions of immunosuppression. A newly described cause of EMN is the multikinase inhibitor sorafenib and its relationship to inhibition of the BRAFV600E mutation (Table).1,2

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Figure 1. Eruptive melanocytic nevi in a patient undergoing treatment with sunitinib. A, Melanocytic nevi located mainly on his back. B, Multiple dark, smooth papules without clinical signs of atypia measuring 2 to 4 mm in diameter. C, Dermoscopic image showing centre pigment stain surrounded by typical pigment reticulum.

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Figure 2. Histologic image of a pigmented lesion on the back. Proliferation of melanocytes in the dermoepidermal junction with nests of melanocytes and melanophages in papillary dermis (hematoxylin-eosin, original magnification ×10).

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