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Correspondence |

Successful Treatment With Vemurafenib in BRAF V600K–Positive Cerebral Melanoma Metastasis

Andrea Forschner, MD; Heike Niessner; Juergen Bauer, MD; Benjamin Bender, MD; Claus Garbe, MD; Friedegund Meier, MD
JAMA Dermatol. 2013;149(5):642-644. doi:10.1001/jamadermatol.2013.372.
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More than 90% of the BRAF mutations in melanoma are identified at codon 600, and about 80% of these are BRAF V600E mutations. The second most common mutation is the BRAF V600K mutation, representing 14% to 28% of BRAF mutations in melanoma.1 Vemurafenib treatment for metastatic melanoma has been extensively studied in patients harboring the BRAF V600E mutation. There are rare data concerning the BRAF V600K mutation.

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Figure 1. A-C, T1-weighted images taken after gadolinium administration and before vemurafenib treatment. Multiple enhancing cerebral metastases (arrows) are seen and a strong dural enhancement, suggestive of meningeal infiltration.

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Figure 2. A-C, T1-weighted images taken after gadolinium administration and 10 weeks after vemurafenib treatment. Cerebral metastases (arrows) have decreased in size and number.

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