Dasatinib, a thiazole carboxamide derivative, is a second-generation tyrosine kinase inhibitor (TKI), similar in structure to imatinib, that is used for the treatment of chronic myelogenous leukemia (CML). We report a case of extensive dasatinib-induced leukotrichia in a patient with refractory CML.
Correspondence: Dr Samimi, Department of Dermatology, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104 (firstname.lastname@example.org).
Conflict of Interest Disclosures: None reported.
Figure 1. Depigmentation of scalp, eyebrow and eyelash hair after 6 months of therapy with dasatinib.
Figure 2. Hair bulb microscopic images (original magnification ×600 for all panels). A, Horizontal section through hair bulb of patient treated with dasatinib (hematoxylin-eosin). B, Melanoma antigen recognized by T cells 1 (MART-1) immunohistochemical stain demonstrates lack of melanocytes in the hair bulb of patient treated with dasatinib. C, Horizontal section through hair bulb of age-matched control patient (hematoxylin-eosin). D, MART-1 immunohistochemical stain highlights melanocytes in the hair bulb of age-matched control patient.
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