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Correspondence |

Dasatinib-Induced Leukotrichia in a Patient With Chronic Myelogenous Leukemia

Sara Samimi, MD; Emily Chu, MD; John Seykora, MD, PhD; Alison Loren, MD; Carmela Vittorio, MD; Alain Rook, MD; Misha Rosenbach, MD; Ellen J. Kim, MD
JAMA Dermatol. 2013;149(5):637-639. doi:10.1001/jamadermatol.2013.75.
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Dasatinib, a thiazole carboxamide derivative, is a second-generation tyrosine kinase inhibitor (TKI), similar in structure to imatinib, that is used for the treatment of chronic myelogenous leukemia (CML). We report a case of extensive dasatinib-induced leukotrichia in a patient with refractory CML.

Correspondence: Dr Samimi, Department of Dermatology, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104 (sara.samimi@uphs.upenn.edu).

Conflict of Interest Disclosures: None reported.

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Figure 1. Depigmentation of scalp, eyebrow and eyelash hair after 6 months of therapy with dasatinib.

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Figure 2. Hair bulb microscopic images (original magnification ×600 for all panels). A, Horizontal section through hair bulb of patient treated with dasatinib (hematoxylin-eosin). B, Melanoma antigen recognized by T cells 1 (MART-1) immunohistochemical stain demonstrates lack of melanocytes in the hair bulb of patient treated with dasatinib. C, Horizontal section through hair bulb of age-matched control patient (hematoxylin-eosin). D, MART-1 immunohistochemical stain highlights melanocytes in the hair bulb of age-matched control patient.

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