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Immediate Successful Treatment of Argyria With a Single Pass of Multiple Q-Switched Laser Wavelengths

Silvija P. Gottesman, MD; Gerald N. Goldberg, MD
JAMA Dermatol. 2013;149(5):623-624. doi:10.1001/jamadermatol.2013.234.
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Argyria is a mucocutaneous discoloration caused by exposure to airborne silver particles or long-term ingestion of ionized silver solutions. It is intriguing in the sense that it creates a profound skin color change. It is known that ionized or colloidal silver particles have the highest affinity for dermal elastic fibers and eccrine glands.1 Once the colloidal silver particles deposit around eccrine glands, they are indeed colorless. It is in the dermal matrix where the silver particles combine with elemental sulfur to form black silver sulfide particles facilitated via a UV-induced reduction reaction.2

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argyria ; lasers

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Figure 1. Our patient with argyria. Note the sparing of the lower eyelids and sun-protected skin underneath patient's hair.

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Figure 2. Our patient after 3 “staged” 1-pass treatments with Q-switched Nd:YAG 1064-nm laser.




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