Research Letters |

Rerecurrence 5 Years After Treatment of Recurrent Cutaneous Basal Cell and Squamous Cell Carcinoma

Jeffrey R. Hamilton, BFA; Rupa Parvataneni, MS; Sarah E. Stuart, BA; Mary-Margaret Chren, MD
JAMA Dermatol. 2013;149(5):616-618. doi:10.1001/jamadermatol.2013.3339.
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Cutaneous basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) that have recurred after previous treatment are considered more difficult to cure compared with primary tumors, with overall 5-year re-recurrence rates reported as high as 15.4%1 for BCC and 5.9% for SCC.2 Few outcomes data exist from prospective studies, but a randomized controlled study in Europe of facial BCCs found that 5-year recurrence rates after excision or Mohs surgery for 397 primary tumors varied from 2.5% to 4.1%, compared with 2.4% to 12.1% for 202 recurrent tumors.3 The generalizability of these results to the United States, to other BCCs and SCCs, and after treatments delivered in the community is not clear. We sought to determine the 5-year recurrence rate after treatment of a consecutive cohort of BCCs and SCCs already recurrent at presentation.

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Figure. Cumulative incidence of recurrence among 1488 primary tumors and 137 recurrent tumors.




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