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Correspondence |

Using Hawthorne Effects to Improve Adherence in Clinical Practice: Lessons From Clinical Trials

Scott A. Davis, MA; Steven R. Feldman, MD, PhD
JAMA Dermatol. 2013;149(4):490-491. doi:10.1001/jamadermatol.2013.2843.
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In their very interesting and well-powered analysis, Gelfand et al1 comment on the phenomenon of systemic treatments for psoriasis showing greater efficacy in clinical trials than in clinical practice. Many reasons for better efficacy in clinical trials are theorized, including different patient populations, more variation in the character of the disease, comorbidities, and differences in raters or rating standards. Another likely cause for better outcomes in clinical trials is that adherence to dermatological treatment is higher in clinical trials than in clinical practice.

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April 1, 2013
Joel M. Gelfand, MD, MSCE; Shuwei Wang, BS; Junko Takeshita, MD, PhD; Andrew D. Robertson, PhD; Gerald G. Krueger, MD; Kristina Callis Duffin, MD; Abby S. Van Voorhees, MD
JAMA Dermatol. 2013;149(4):490-491. doi:10.1001/jamadermatol.2013.2846.
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