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Observation |

Cutaneous Features of Crouzon Syndrome With Acanthosis Nigricans FREE

Adnan Mir, MD, PhD; Timothy Wu, BA; Seth J. Orlow, MD, PhD
[+] Author Affiliations

Author Affiliations: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.


JAMA Dermatol. 2013;149(6):737-741. doi:10.1001/jamadermatol.2013.3019.
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Published online

ABSTRACT

Importance Crouzon syndrome with acanthosis nigricans is a distinct disorder caused by a mutation in the FGFR3 gene, featuring craniosynostosis, characteristic facial features, and atypical and extensive acanthosis nigricans. Other cutaneous findings have not been thoroughly described.

Observations We report 6 cases and summarize the existing literature with regard to the cutaneous manifestations of this disorder. All patients have widespread, early-onset acanthosis nigricans. Patients often have prominent hypopigmented scars at surgical sites and nevi arising early in childhood.

Conclusions and Relevance In addition to craniofacial malformations, Crouzon syndrome with acanthosis nigricans results in characteristic cutaneous findings.

Figures in this Article

Acanthosis nigricans (AN) associated with Crouzon syndrome was initially described in the 1960s as an unusual subtype of AN.1 Since then, more than 35 case reports of this genetically distinct disorder known as Crouzon syndrome with acanthosis nigricans (CSAN) have been described.217 Typical craniofacial and skeletal features of CSAN overlap with classic Crouzon syndrome; all described cases present with craniosynostosis, proptosis, hypertelorism, posteriorly rotated ears, and midface hypoplasia. In addition, patients with CSAN often present with choanal atresia and hydrocephalus, which are absent in classic Crouzon syndrome.18

Unlike classic Crouzon syndrome, which lacks any specific cutaneous features, the presence of AN is essential for the clinical diagnosis of CSAN. Affected individuals develop early-onset, severe, and widespread rugose thickening and hyperpigmentation of the skin; 2 reports describe the presence of AN at birth.9,14 In addition to the most common locations on the neck and axillae, patients with CSAN are affected periorally and periorbitally, on the chest, around the umbilicus, and on the breasts. Notably, the endocrine abnormality typical of patients with AN is lacking.19

Compared with Crouzon syndrome, which results from mutations in the fibroblast growth factor receptor 2 gene (FGFR2 [OMIM 176943]) on chromosome 10q26.13, CSAN is caused by a specific missense mutation in the fibroblast growth factor receptor 3 gene (FGFR3 [OMIM 134934]) on chromosome 4p16.3, which leads to an Ala391Glu substitution and results in constitutive activation of the receptor.18 The rare disorder is inherited in an autosomal dominant fashion, although most cases are sporadic mutations. The diagnosis is generally made clinically and based on the highly distinctive constellation of findings; genetic testing is not routinely performed. As with other disorders caused by FGFR mutations, increased paternal age appears to be a risk factor.16 Female patients appear to predominate, and no racial predilection has been noted. Different FGFR3 mutations have been linked to the development of severe AN associated with multiple forms of achondroplasia and to AN without notable craniofacial or skeletal defects.2022 Localized somatic mutations in the FGFR3 gene also underlie benign neoplastic epidermal proliferations, such as seborrheic keratoses, lentigines, and dermatosis papulosa nigra.2325

The finding of AN in patients with CSAN is severe and widespread. Unlike commonly found AN, CSAN is independent of endocrine abnormalities, driven instead by the activation of FGFR3.19,26 In addition to AN, development of melanocytic nevi and hypopigmented postsurgical scars is common.2,3,6,13 Verrucous lesions and café au lait macules also develop in a few patients.13,17 In this report, we describe the cutaneous features of 6 cases of CSAN and review previously reported cases.

REPORT OF CASES

We identified 6 cases of CSAN evaluated in a university-based pediatric dermatology practice from January 1, 1992, through December 31, 2008, by searching the electronic medical record for the International Classification of Diseases, Ninth Revision code for AN. In addition, we identified 38 previously published cases of CSAN by performing a PubMed search using the terms Crouzon and acanthosis nigricans. Of those cases, 27 had sufficient cutaneous findings to be included in this study. One of the patients included herein has been described in a previous publication, but we included the patient with further description of the cutaneous findings. The clinical features of these patients are presented in the Table. We found no discernible racial predilection for CSAN. The ratio of female to male patients was 2:1. Mutational analysis was performed in 16 patients, all of whom were found to carry the Ala391Glu substitution in FGFR3.

Table Graphic Jump LocationTable. Summary of Clinical Presentations in the Present Series and in a Literature Review of Patients With CSAN
ACANTHOSIS NIGRICANS

For the 27 cases in which it has been reported, the mean age at onset of AN was about 4.5 years, with 2 patients affected at birth. Acanthosis nigricans was invariably present on the neck, and in 25 of 31 patients (81%), in the axillae (all 6 [100%] in the present study, and including involvement of the “flexors” described in 2 cases). Acanthosis nigricans was also found on the face (21 of 31 [68%]), chest (13 of 31 [42%]), abdomen (14 of 31 [45%]), groin (9 of 31 [29%]), upper extremities (7 of 31 [23%]), lower extremities (3 of 31 [10%]), and lower back (2 of 31 [6%]); the total number excludes cases in which location was not described. Acanthosis nigricans on the face was found around the eyelids, eyes, mouth, nose, and ears (Figure 1). On the abdomen, we found a predilection for the periumbilical area; on the extremities, in the antecubital and popliteal fossae. The neck and axillae were usually more severely affected (Figure 2). In most patients over time, the AN was severe, giving the skin an appearance resembling the bark of an oak tree.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. Acanthosis nigricans on the face of a patient with Crouzon syndrome with acanthosis nigricans at 16 years of age.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Severe acanthosis nigricans in a patient with Crouzon syndrome with acanthosis nigricans. A, Neck. B, Axilla.

MELANOCYTIC NEVI

Dark nevi have been reported previously in 7 patients with CSAN, with a predilection for the face. Of our 6 patients, 5 had melanocytic nevi, all of them dark. Most nevi were present on the trunk, with a few on the extremities. They were uniformly dark brown, symmetric, and well demarcated, without variegation or other atypical features. On dermoscopy in 2 patients, all nevi were of the globular pattern (Figure 3A). Nevi seemed more prominent in areas affected by AN.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 3. Two patients with Crouzon syndrome with acanthosis nigricans (AN). A, Dark melanocytic nevi, which are globular in dermoscopic pattern. B and C, Hypopigmented scars on a background of AN.

HYPOPIGMENTED SCARS

Prominent, hypopigmented postsurgical scarring was reported in 5 patients with CSAN and observed in 5 of the 6 patients in the present study (Figure 3B and C). In all patients, the scarring was within areas of AN. The most typical location was the tracheostomy site on the neck, which tends to be the darkest area of AN. The patient in the present study who was not affected had the mildest AN.

OTHER CUTANEOUS FINDINGS

Several other cutaneous findings were noted in the present study. Sacral pits associated with pink plaques were present in 2 patients, verrucae vulgaris were present in 2 patients, and another presented with molluscum contagiosum. Three patients had seborrheic dermatitis of the scalp, which developed at 8 years of age in two and at 22 years of age in the third. One patient was diffusely xerotic, a finding reported previously in 4 patients. The hair and nails of all patients were normal.

COMMENT

Crouzon syndrome with AN is a distinct genetic disease caused in all cases by a specific mutation in FGFR3. Previous studies have focused largely on craniofacial and skeletal abnormalities in affected patients. Although many reports describe the associated AN, other cutaneous manifestations have been poorly characterized.

Acanthosis nigricans in affected patients is most severe on the neck and axillae. The face and trunk are also affected in most of these patients. In classic AN related to an endocrine abnormality, these areas are typically unaffected. The limbs were relatively spared in CSAN. Another interesting and further disfiguring result of this pattern is the presence of striking hypopigmented scars at sites of prior operations. Indeed, most patients with CSAN have had many surgical procedures. These surgical sites heal without AN, leaving prominent, flat, white scars on a background of hyperpigmentation and thick skin. The scars are distinctive in that, unlike surgical scars in unaffected individuals, they are never red and remain profoundly hypopigmented, even after many years.

Dark melanocytic nevi have been reported in children with CSAN, although nevus counts compared with matched healthy controls have not been reported. These nevi tend to be dark brown, uniform lesions without suspicious features. In 2 of our patients whose nevi we examined dermoscopically, the globular pattern was found. This finding is not surprising because it is the most common pattern seen in the first 2 decades of life.28 The significance of the presence of nevi in patients with CSAN is unclear. Although aberrant activation of FGFR3 clearly affects keratinocyte proliferation, as indicated by its role in the pathogenesis of AN, epidermal nevi, and seborrheic keratosis, aberrant activation has been ascribed no direct role in melanocyte proliferation.

Less common cutaneous manifestations of CSAN have been noted. Two of our patients, one of whom was Japanese and the other white, had sacral pits associated with pink plaques. The significance of these findings is unknown. Seborrheic dermatitis of the scalp, a common condition, nonetheless appeared relatively overrepresented in the available data. In addition, isolated findings such as molluscum contagiosum, acne, skin hyperelasticity, and café au lait macules are likely unrelated. More investigation is needed to determine whether further relevant cutaneous manifestations are associated with CSAN.

Although we have not formally studied the psychosocial effects of the disfiguring AN variant in CSAN, all parents and patients old enough to express an opinion were desirous of treatment if available. To date, little success has been achieved in the amelioration of the AN when associated with Crouzon syndrome. Unlike common AN of endocrine origin, little can address the underlying cause in CSAN. Some of our patients had modest improvement from the use of topical alpha hydroxy acids or retinoids. However, any improvement seen was lost after discontinuation of the treatment. Because of the similarity of AN to confluent and reticulate papillomatosis (Gougerot-Carteaud syndrome), minocycline hydrochloride was prescribed to 2 patients; this treatment has been shown to be effective in confluent and reticulated papillomatosis.29,30 This treatment resulted in temporary modest improvement but no lasting benefit. Our best results have been achieved by rotating agents as they start to lose effectiveness.

ARTICLE INFORMATION

Correspondence: Seth J. Orlow, MD, PhD, The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 240 E 38th St, 11th Floor, New York, NY 10016 (seth.orlow@nyumc.org).

Accepted for Publication: November 30, 2012.

Published Online: April 9, 2013. doi:10.1001/jamadermatol.2013.3019

Author Contributions: All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Mir and Orlow. Acquisition of data: Mir and Wu. Analysis and interpretation of data: Mir, Wu, and Orlow. Drafting of the manuscript: Mir and Wu. Critical revision of the manuscript for important intellectual content: Mir and Orlow. Administrative, technical, and material support: Orlow. Study supervision: Orlow.

Conflict of Interest Disclosures: None reported.

Additional Contributions: Mary Spano, New York University Institute of Reconstructive Plastic Surgery, provided expert photographic services.

REFERENCES

Curth HO. The Necessity of Distinguishing Four Types of Acanthosis Nigricans. Vol 1. Berlin, Germany: Springer-Verlag; 1968
Arnaud-López L, Fragoso R, Mantilla-Capacho J, Barros-Núñez P. Crouzon with acanthosis nigricans: further delineation of the syndrome.  Clin Genet. 2007;72(5):405-410
PubMed   |  Link to Article
Breitbart AS, Eaton C, McCarthy JG. Crouzon's syndrome associated with acanthosis nigricans: ramifications for the craniofacial surgeon.  Ann Plast Surg. 1989;22(4):310-315
PubMed   |  Link to Article
Di Rocco F, Collet C, Legeai-Mallet L,  et al.  Crouzon syndrome with acanthosis nigricans: a case-based update.  Childs Nerv Syst. 2011;27(3):349-354
PubMed   |  Link to Article
Friedhofer H, Ocharan AM, Sturtz GP, Fonseca AS, Coltro PS, Ferreira MC. Surgical treatment for eyelid deformity in Crouzon syndrome associated with acanthosis nigricans: case report.  Clinics (Sao Paulo). 2006;61(2):171-174
PubMed   |  Link to Article
Gines E, Rodriguez-Pichardo A, Jorquera E, Moreno JC, Camacho F. Crouzon disease with acanthosis nigricans and melanocytic nevi.  Pediatr Dermatol. 1996;13(1):18-21
PubMed   |  Link to Article
Gupta AK, Koley S, Choudhary S, Bhake A, Saoji V, Salodkar A. A rare association of acanthosis nigricans with Crouzon syndrome.  Indian J Dermatol Venereol Leprol. 2010;76(1):65-67
PubMed   |  Link to Article
Jeftha A, Stephen L, Morkel JA, Beighton P. Crouzonodermoskeletal syndrome.  J Clin Pediatr Dent. 2004;28(2):173-176
PubMed
Koizumi H, Tomoyori T, Sato KC, Ohkawara A. An association of acanthosis nigricans and Crouzon syndrome.  J Dermatol. 1992;19(2):122-126
PubMed
Lapunzina P, Fernández MC, Varela Junquera JM, Arberas C, Tello AM, Gracia Bouthelier R. Crouzon's syndrome with acanthosis nigricans.  An Esp Pediatr. 2002;56(4):342-346
PubMed   |  Link to Article
Nagase T, Nagase M, Hirose S, Ohmori K. Crouzon syndrome with acanthosis nigricans: case report and mutational analysis.  Cleft Palate Craniofac J. 2000;37(1):78-82
PubMed   |  Link to Article
Reddy BS, Garg BR, Padiyar NV, Krishnaram AS. An unusual association of acanthosis nigricans and Crouzon's disease: a case report.  J Dermatol. 1985;12(1):85-90
PubMed
Schweitzer DN, Graham JM Jr, Lachman RS,  et al.  Subtle radiographic findings of achondroplasia in patients with Crouzon syndrome with acanthosis nigricans due to an Ala391Glu substitution in FGFR3.  Am J Med Genet. 2001;98(1):75-91
PubMed   |  Link to Article
Sharda S, Panigrahi I, Gupta K, Singhi S, Kumar R. A newborn with acanthosis nigricans: can it be Crouzon syndrome with acanthosis nigricans?  Pediatr Dermatol. 2010;27(1):43-47
PubMed   |  Link to Article
Suslak L, Glista B, Gertzman GB, Lieberman L, Schwartz RA, Desposito F. Crouzon syndrome with periapical cemental dysplasia and acanthosis nigricans: the pleiotropic effect of a single gene?  Birth Defects Orig Artic Ser. 1985;21(2):127-134
PubMed
Vajo Z, Francomano CA, Wilkin DJ. The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans.  Endocr Rev. 2000;21(1):23-39
PubMed   |  Link to Article
Wilkes D, Rutland P, Pulleyn LJ,  et al.  A recurrent mutation, Ala391Glu, in the transmembrane region of FGFR3 causes Crouzon syndrome and acanthosis nigricans.  J Med Genet. 1996;33(9):744-748
PubMed   |  Link to Article
Meyers GA, Orlow SJ, Munro IR, Przylepa KA, Jabs EW. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans.  Nat Genet. 1995;11(4):462-464
PubMed   |  Link to Article
Orlow SJ. Cutaneous findings in craniofacial malformation syndromes.  Arch Dermatol. 1992;128(10):1379-1386
PubMed   |  Link to Article
Baker KM, Olson DS, Harding CO, Pauli RM. Long-term survival in typical thanatophoric dysplasia type 1.  Am J Med Genet. 1997;70(4):427-436
PubMed   |  Link to Article
Berk DR, Spector EB, Bayliss SJ. Familial acanthosis nigricans due to K650T FGFR3 mutation.  Arch Dermatol. 2007;143(9):1153-1156
PubMed   |  Link to Article
Tavormina PL, Bellus GA, Webster MK,  et al.  A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene.  Am J Hum Genet. 1999;64(3):722-731
PubMed   |  Link to Article
Hafner C, Landthaler M, Mentzel T, Vogt T. FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra.  Br J Dermatol. 2010;162(3):508-512
PubMed   |  Link to Article
Hafner C, Vogt T, Hartmann A. FGFR3 mutations in benign skin tumors.  Cell Cycle. 2006;5(23):2723-2728
PubMed   |  Link to Article
Hafner C, Vogt T, Landthaler M, Müsebeck J. Somatic FGFR3 and PIK3CA mutations are present in familial seborrhoeic keratoses.  Br J Dermatol. 2008;159(1):214-217
PubMed   |  Link to Article
Alatzoglou KS, Hindmarsh PC, Brain C, Torpiano J, Dattani MT. Acanthosis nigricans and insulin sensitivity in patients with achondroplasia and hypochodroplasia due to FGFR3 mutations.  J Clin Endocrinol Metab. 2009;94(10):3959-3963
PubMed   |  Link to Article
Witkowski JA, Parish LC. A new face for Crouzon's syndrome.  Int J Dermatol. 1976;15(6):444-445
Link to Article
Zalaudek I, Schmid K, Marghoob AA,  et al.  Frequency of dermoscopic nevus subtypes by age and body site: a cross-sectional study.  Arch Dermatol. 2011;147(6):663-670
PubMed   |  Link to Article
Davis MD, Weenig RH, Camilleri MJ. Confluent and reticulate papillomatosis (Gougerot-Carteaud syndrome): a minocycline-responsive dermatosis without evidence for yeast in pathogenesis: a study of 39 patients and a proposal of diagnostic criteria.  Br J Dermatol. 2006;154(2):287-293
PubMed   |  Link to Article
Yamamoto A, Okubo Y, Oshima H, Oh-i T, Koga M. Two cases of confluent and reticulate papillomatosis: successful treatments of one case with cefdinir and another with minocycline.  J Dermatol. 2000;27(9):598-603
PubMed

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. Acanthosis nigricans on the face of a patient with Crouzon syndrome with acanthosis nigricans at 16 years of age.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Severe acanthosis nigricans in a patient with Crouzon syndrome with acanthosis nigricans. A, Neck. B, Axilla.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 3. Two patients with Crouzon syndrome with acanthosis nigricans (AN). A, Dark melanocytic nevi, which are globular in dermoscopic pattern. B and C, Hypopigmented scars on a background of AN.

Tables

Table Graphic Jump LocationTable. Summary of Clinical Presentations in the Present Series and in a Literature Review of Patients With CSAN

References

Curth HO. The Necessity of Distinguishing Four Types of Acanthosis Nigricans. Vol 1. Berlin, Germany: Springer-Verlag; 1968
Arnaud-López L, Fragoso R, Mantilla-Capacho J, Barros-Núñez P. Crouzon with acanthosis nigricans: further delineation of the syndrome.  Clin Genet. 2007;72(5):405-410
PubMed   |  Link to Article
Breitbart AS, Eaton C, McCarthy JG. Crouzon's syndrome associated with acanthosis nigricans: ramifications for the craniofacial surgeon.  Ann Plast Surg. 1989;22(4):310-315
PubMed   |  Link to Article
Di Rocco F, Collet C, Legeai-Mallet L,  et al.  Crouzon syndrome with acanthosis nigricans: a case-based update.  Childs Nerv Syst. 2011;27(3):349-354
PubMed   |  Link to Article
Friedhofer H, Ocharan AM, Sturtz GP, Fonseca AS, Coltro PS, Ferreira MC. Surgical treatment for eyelid deformity in Crouzon syndrome associated with acanthosis nigricans: case report.  Clinics (Sao Paulo). 2006;61(2):171-174
PubMed   |  Link to Article
Gines E, Rodriguez-Pichardo A, Jorquera E, Moreno JC, Camacho F. Crouzon disease with acanthosis nigricans and melanocytic nevi.  Pediatr Dermatol. 1996;13(1):18-21
PubMed   |  Link to Article
Gupta AK, Koley S, Choudhary S, Bhake A, Saoji V, Salodkar A. A rare association of acanthosis nigricans with Crouzon syndrome.  Indian J Dermatol Venereol Leprol. 2010;76(1):65-67
PubMed   |  Link to Article
Jeftha A, Stephen L, Morkel JA, Beighton P. Crouzonodermoskeletal syndrome.  J Clin Pediatr Dent. 2004;28(2):173-176
PubMed
Koizumi H, Tomoyori T, Sato KC, Ohkawara A. An association of acanthosis nigricans and Crouzon syndrome.  J Dermatol. 1992;19(2):122-126
PubMed
Lapunzina P, Fernández MC, Varela Junquera JM, Arberas C, Tello AM, Gracia Bouthelier R. Crouzon's syndrome with acanthosis nigricans.  An Esp Pediatr. 2002;56(4):342-346
PubMed   |  Link to Article
Nagase T, Nagase M, Hirose S, Ohmori K. Crouzon syndrome with acanthosis nigricans: case report and mutational analysis.  Cleft Palate Craniofac J. 2000;37(1):78-82
PubMed   |  Link to Article
Reddy BS, Garg BR, Padiyar NV, Krishnaram AS. An unusual association of acanthosis nigricans and Crouzon's disease: a case report.  J Dermatol. 1985;12(1):85-90
PubMed
Schweitzer DN, Graham JM Jr, Lachman RS,  et al.  Subtle radiographic findings of achondroplasia in patients with Crouzon syndrome with acanthosis nigricans due to an Ala391Glu substitution in FGFR3.  Am J Med Genet. 2001;98(1):75-91
PubMed   |  Link to Article
Sharda S, Panigrahi I, Gupta K, Singhi S, Kumar R. A newborn with acanthosis nigricans: can it be Crouzon syndrome with acanthosis nigricans?  Pediatr Dermatol. 2010;27(1):43-47
PubMed   |  Link to Article
Suslak L, Glista B, Gertzman GB, Lieberman L, Schwartz RA, Desposito F. Crouzon syndrome with periapical cemental dysplasia and acanthosis nigricans: the pleiotropic effect of a single gene?  Birth Defects Orig Artic Ser. 1985;21(2):127-134
PubMed
Vajo Z, Francomano CA, Wilkin DJ. The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans.  Endocr Rev. 2000;21(1):23-39
PubMed   |  Link to Article
Wilkes D, Rutland P, Pulleyn LJ,  et al.  A recurrent mutation, Ala391Glu, in the transmembrane region of FGFR3 causes Crouzon syndrome and acanthosis nigricans.  J Med Genet. 1996;33(9):744-748
PubMed   |  Link to Article
Meyers GA, Orlow SJ, Munro IR, Przylepa KA, Jabs EW. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans.  Nat Genet. 1995;11(4):462-464
PubMed   |  Link to Article
Orlow SJ. Cutaneous findings in craniofacial malformation syndromes.  Arch Dermatol. 1992;128(10):1379-1386
PubMed   |  Link to Article
Baker KM, Olson DS, Harding CO, Pauli RM. Long-term survival in typical thanatophoric dysplasia type 1.  Am J Med Genet. 1997;70(4):427-436
PubMed   |  Link to Article
Berk DR, Spector EB, Bayliss SJ. Familial acanthosis nigricans due to K650T FGFR3 mutation.  Arch Dermatol. 2007;143(9):1153-1156
PubMed   |  Link to Article
Tavormina PL, Bellus GA, Webster MK,  et al.  A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene.  Am J Hum Genet. 1999;64(3):722-731
PubMed   |  Link to Article
Hafner C, Landthaler M, Mentzel T, Vogt T. FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra.  Br J Dermatol. 2010;162(3):508-512
PubMed   |  Link to Article
Hafner C, Vogt T, Hartmann A. FGFR3 mutations in benign skin tumors.  Cell Cycle. 2006;5(23):2723-2728
PubMed   |  Link to Article
Hafner C, Vogt T, Landthaler M, Müsebeck J. Somatic FGFR3 and PIK3CA mutations are present in familial seborrhoeic keratoses.  Br J Dermatol. 2008;159(1):214-217
PubMed   |  Link to Article
Alatzoglou KS, Hindmarsh PC, Brain C, Torpiano J, Dattani MT. Acanthosis nigricans and insulin sensitivity in patients with achondroplasia and hypochodroplasia due to FGFR3 mutations.  J Clin Endocrinol Metab. 2009;94(10):3959-3963
PubMed   |  Link to Article
Witkowski JA, Parish LC. A new face for Crouzon's syndrome.  Int J Dermatol. 1976;15(6):444-445
Link to Article
Zalaudek I, Schmid K, Marghoob AA,  et al.  Frequency of dermoscopic nevus subtypes by age and body site: a cross-sectional study.  Arch Dermatol. 2011;147(6):663-670
PubMed   |  Link to Article
Davis MD, Weenig RH, Camilleri MJ. Confluent and reticulate papillomatosis (Gougerot-Carteaud syndrome): a minocycline-responsive dermatosis without evidence for yeast in pathogenesis: a study of 39 patients and a proposal of diagnostic criteria.  Br J Dermatol. 2006;154(2):287-293
PubMed   |  Link to Article
Yamamoto A, Okubo Y, Oshima H, Oh-i T, Koga M. Two cases of confluent and reticulate papillomatosis: successful treatments of one case with cefdinir and another with minocycline.  J Dermatol. 2000;27(9):598-603
PubMed

Correspondence

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For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
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