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Correspondence |

Phymatous Transformation of Facial Cutaneous Vascular Malformations: Clues to Phyma Pathogenesis

Harald Voth, MD; Jörg Wenzel, MD; Thomas Bieber, MD, PhD; Jennifer Landsberg, MD
JAMA Dermatol. 2013;149(3):368-369. doi:10.1001/jamadermatol.2013.1213.
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Phymas are benign tumors of the face caused by hypertrophy of sebaceous glands and connective tissue. They are pathognomonic for rosacea, a common centrofacial inflammatory dermatosis of unknown origin. In spite of various factors that have been implicated in its etiopathology, including genetic susceptibility, vascular disturbances, dysregulation of the innate immune response, dermal matrix degeneration, actinic damage, and microbial organisms, the exact pathogenesis of rosacea and its different clinical manifestations remains unknown.

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Figure 1. Phymatous transformation of a cutaneous vascular malformation in a 52-year-old male patient.

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Figure 2. Histologic evaluation of phymatously transformed vascular malformation (vascular endothelial growth factor receptor 2, original magnification ×20).




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