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Finasteride for the Treatment of Hidradenitis Suppurativa in Children and Adolescents FREE

Harkamal Kaur Randhawa, MD; Jill Hamilton, MD; Elena Pope, MD
[+] Author Affiliations

Author Affiliations: Hospital for Sick Children, Toronto, Ontario, Canada.


JAMA Dermatol. 2013;149(6):732-735. doi:10.1001/jamadermatol.2013.2874.
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Published online

ABSTRACT

Importance Hidradenitis suppurativa (HS) is a chronic debilitating cutaneous disease for which there is no universally effective treatment. Patients typically present at puberty with tender subcutaneous nodules that can progress to dermal abscess formation. Antiandrogens have been used in the treatment of HS, and studies have primarily focused on adult patients.

Observations We present a case series of 3 pediatric patients with HS who were successfully treated with oral finasteride, resulting in decreased frequency and severity of disease flares with no significant adverse effects.

Conclusions and Relevance Finasteride is a therapeutic option that provides benefit for pediatric patients with HS. Further prospective data and randomized controlled studies will provide helpful information in the management of this disease.

Figures in this Article

Hidradenitis suppurativa (HS) is a chronic inflammatory disease that primarily involves skin in the axillae, groin, and anogenital regions, although disease may extend to the buttocks, chest, scalp, eyelids, and retroauricular areas.1 Patients with HS develop exquisitely painful erythematous subcutaneous nodules that may heal spontaneously or suppurate and coalesce to form dermal abscesses. There may be subsequent sinus tract formation and severe scarring. Typically, disease onset occurs in the second or third decade of life.2 Although HS may be seen in prepubertal patients,25 fewer than 2% of cases occur before the age of 11 years.2 Patients with HS often report a significant negative effect on quality of life, due not only to physical symptoms but also to social stigma associated with the disease.6 Although multiple medical treatments exist, including antimicrobials, immunosuppressants, and hormonal, laser, and surgical therapies, no single treatment modality has been found to be universally effective.7 Antiandrogenic medications are among those used to treat HS, but, to our knowledge, there are no published pediatric case series regarding the use of this treatment. We would like to highlight the use of finasteride as another potential therapy for HS in children; finasteride is an antiandrogen with a mechanism of action different from that of cyproterone acetate, a previously studied antiandrogen in patients with HS. We outline findings in 3 cases presenting during childhood, all in patients who showed significant improvement in disease activity with finasteride treatment.

REPORT OF CASES

PATIENT 1

A 6-year-old girl presented with precocious puberty. She developed painful inflamed nodules in the groin at 7 years. During the subsequent year, she had an increase in the number and size of these lesions. She was initially treated by her community physician with topical and oral antibiotics with no success. She also had been taking a 4-month course of isotretinoin, which did not improve her HS lesions. At the time she presented to us at age 13 years, she had extensive lesions consistent with HS in the groin and axillae. There were large, tender, inflamed nodules extending to the perianal, perineal regions, and inner thighs. Surgical resection of tissue from the left axilla was explored as an option for extensive axillary disease, but ultimately the surgical team suggested to pursue medical management. She continued to develop extensive lesions in the axillae, flanks, groin, and inner thighs. She was started on oral minocycline with no significant improvement. Two months later, she was given oral Marvelon (ethinyl estradiol, 0.03 mg, and desogestrel, 0.15 mg, on menstrual cycle days 1 through 21). Six months later, there was mild to moderate improvement, and oral spironolactone was added to augment her therapy. At 13½ years of age, she continued to have further flares, requiring oral cephalexin on 2 occasions. At age 14 years, she had a significant flare-up in the axillae, groin, lower abdomen, and inner thighs, requiring a 6-week course of oral cephalexin. She was experiencing considerable emotional distress as a result of her skin disease. She commenced photodynamic therapy at age 14½ years, and minocycline was switched to tetracycline hydrochloride, in addition to spironolactone, and oral contraceptive (OC). She underwent amino levulinic acid photodynamic therapy (ALA-PDL) monthly. Initially, there was minimal improvement with ALA-PDL. At 15¼ years, spironolactone was stopped and finasteride, 5 mg/d, was started and increased 3 months later to 10 mg/d. In conjunction with ALA-PDL and OCs, escalation of finasteride to 10 mg/d resulted in clinical improvement with reduction in frequency and severity of flares. Oral tetracycline hydrochloride was stopped 6 months after maximum finasteride dose was achieved. During the next 3 years, she had only 3 flares, each of which were treated successfully with brief courses of oral cephalexin. She has currently been receiving this treatment for 6 years.

PATIENT 2

A 15-year-old girl with polycystic ovary syndrome, diagnosed 1 month prior, presented with a 1-year history of severe HS lesions in the groin region and on the posterior part of the neck, requiring surgical drainage and intravenous antibiotics. She continued to have flares during treatment with isotretinoin and an OC, which were started within 2 months of presentation. During the next 6 weeks, she had 2 significant flares, one of which required hospitalization for intravenous antibiotics. Oral erythromycin estolate was given in combination with OCs and isotretinoin. However, the flares persisted for the next month. Isotretinoin was stopped at age 15½ years due to poor response to treatment, and oral finasteride, 5 mg/d, was started at that time, in addition to oral erythromycin and OC. With this therapeutic combination, the patient's disease flares have decreased in frequency and severity during the next 2½ years at this writing.

PATIENT 3

A 7-year-old girl presented with a 1-year history of perianal, inner thigh, and axillary disease (Figure 1 and Figure 2) consisting of painful nodules that would occur every few weeks to months. A biopsy showed inflamed cysts, and she was treated with oral erythromycin for 2 months with no improvement in her condition. The patient was unable to attend school because of pain and her inability to sit for a protracted time. Erythromycin was stopped, and she was treated with a combination of topical clindamycin phosphate (1%) and benzoyl peroxide (5%) gel, oral trimethoprim, and oral finasteride, 1.25 mg/d. After 9 weeks of receiving this treatment regimen, there was minimal improvement, so topical silver sulfadiazine was recommended and the finasteride dose was increased to 2.5 mg/d. Three months later, the finasteride dose was increased to 5 mg/d because she continued to see new inflammatory lesions in addition to comedones. Topical adapalene, 0.3% daily, was used as needed for comedones, and trimethoprim dose was increased slightly. At 9 years of age, she noted significant improvement in symptoms and very rare need for topical antibiotics, so her trimethoprim dose was decreased and she continued receiving finasteride, 5 mg/d. She reported only rare need for topical adapalene. She has since continued oral trimethoprim and finasteride, as well as topical clindamycin phosphate (1% wipes) to the groin and axillae if she has heavy perspiration with physical activity. After 1 year of oral trimethoprim and an escalating dose of finasteride (up to 5 mg/d), the patient's condition showed remarkable improvement, with minimal flares (Figure 3 and Figure 4). She has continued to receive this treatment for a total of 3 years.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. At initial presentation, patient 3 had multiple inflammatory erythematous nodules on both inner thighs.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Patient 3 had tender erythematous nodules in the perianal region at presentation.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 3. After 3 years of finasteride therapy, patient 3 showed significant resolution of active disease, with a decrease in inflammatory nodules and residual scarring and dyspigmentation on the inner thighs.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 4. Patient 3 had residual scarring and dyspigmentation in the perianal area after 3 years of finasteride therapy.

COMMENT

For many years, androgens have been suggested as a causative or contributing factor for HS. Initial studies demonstrated that female patients with HS had higher concentrations of plasma testosterone and a higher free androgen index than control participants, suggesting that androgens play a role in the pathophysiology of this condition.8 A subsequent study challenged these findings by examining androgen levels in female patients with HS and controls matched for weight and hirsutism. This study found no difference in plasma testosterone or dehydroepiandrosterone levels between patients and controls.9 Nevertheless, clinical experience with antiandrogens has yielded positive results in some studies. In a randomized controlled trial comparing treatment with ethinyl estradiol (50 μg) and either cyproterone acetate (50 mg) or norgestrel (500 μg) in 24 female patients, significant improvement in disease activity was shown for both treatment groups.10 Other case series have also shown therapeutic benefit for antiandrogens in some patients with HS.1113

Finasteride is a competitive inhibitor of the type II 5α-reductase enzyme, which converts testosterone to dihydrotestosterone, resulting in decreased serum dihydrotestosterone levels. Type II 5α-reductase is found in hair follicles, whereas type I 5α-reductase is present in both hair follicles and apocrine glands.14 Although HS has historically been considered a disease of the apocrine glands, there is some evidence that its primary mechanism is inflammation of the terminal follicular epithelium with apocrine involvement as a secondary phenomenon.15,16 Accordingly, inhibition of 5α-reductase could improve symptoms of HS by reducing local concentrations of dihydrotestosterone at the level of the hair follicles. This would explain why other antiandrogens that act by blocking dihydrotestosterone at the receptor level more globally, such as cyproterone acetate, have not been shown to be universally effective.

Finasteride is typically used in male patients to treat androgenic alopecia17 or benign prostatic hyperplasia18 and less commonly in female patients with hirsutism.19 The major safety issues with finasteride include its potential to cause feminization of the male fetus in women of reproductive age20 and an association between daily finasteride use and increased risk of high-grade prostate cancer in men older than 50 years. In a retrospective pediatric study of male patients with androgenetic alopecia treated with oral finasteride for 6 months to 8 years, the only adverse effect noted was transient sexual dysfunction.21 Our patients were treated with finasteride in combination with OCs and/or oral antibiotics. However, there have been 2 reports of successful treatment of severe HS with finasteride as monotherapy in adults.12,22 One case series of 7 patients treated with finasteride (5 mg/d) for disease not responsive to antibiotics demonstrated significant improvement in 6 or 7 patients and prolonged remission in 2.12 Adverse effects noted in that study included generalized pruritus that resolved with cessation of treatment in 1 male patient and breast enlargement and premenstrual tenderness in 2 female patients, 1 of whom experienced this effect for a year.12

To our knowledge, no long-term safety studies for finasteride have been performed in the pediatric population. Studies in adults examining the effects of finasteride on sperm count and motility showed no significant effect after 1 year of treatment,23 but there have been a few case reports of reversible negative effects on spermatogenesis and 2 reports of an association with infertility.24,25 Currently, finasteride is categorized as pregnancy category X26 and contraindicated in female patients of childbearing age owing to the risk of feminization of a male fetus. Therefore, decisions to use this medication in female patients should be carefully considered, and the risks should be clearly communicated to patients. Addition of OCs may be a suitable therapeutic strategy for patients of childbearing age.

Our initial experience and findings suggest that finasteride may be a suitable additive therapy for refractory cases of HS. We propose that finasteride be considered in patients with HS for whom topical or oral antibiotics have not yielded adequate improvement and before intervention with surgical or biologic therapies. In the absence of long-term safety data in children and adolescents, we recommend judicious use of finasteride, with clear communication regarding risks and benefits; adjunctive use of OC therapy should be considered in menstruating female patients.

ARTICLE INFORMATION

Correspondence: Harkamal Kaur Randhawa, MD, Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada (harkamal.randhawa@sickkids.ca).

Accepted for Publication: November 12, 2012.

Published Online: March 20, 2013. doi:10.1001/jamadermatol.2013.2874

Author Contributions: All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Hamilton and Pope. Acquisition of data: Randhawa. Analysis and interpretation of data: All authors. Drafting of the manuscript: Randhawa and Pope. Critical revision of the manuscript for important intellectual content: Hamilton and Pope. Administrative, technical, or material support: Randhawa and Pope. Study supervision: Hamilton and Pope.

Conflict of Interest Disclosures: None reported.

Additional Contributions: The authors acknowledge Michelle V. Lee, RN, for facilitating use of photographic and case materials.

REFERENCES

Slade DE, Powell BW, Mortimer PS. Hidradenitis suppurativa: pathogenesis and management.  Br J Plast Surg. 2003;56(5):451-461
PubMed   |  Link to Article
Palmer RA, Keefe M. Early-onset hidradenitis suppurativa.  Clin Exp Dermatol. 2001;26(6):501-503
PubMed   |  Link to Article
Jourdain JC, Le Lorier B, Mourier C, Ploussard JP, Roussel F. Virilisation par deficit en 21-hydroxylase et hyperplasie sudorale axillaire.  Ann Dermatol Venereol. 1988;115(11):1136-1138
PubMed
Lewis F, Messenger AG, Wales JKH. Hidradenitis suppurativa as a presenting feature of premature adrenarche.  Br J Dermatol. 1993;129(4):447-448
PubMed   |  Link to Article
Mengesha YM, Holcombe TC, Hansen RC. Prepubertal hidradenitis suppurativa: two case reports and review of the literature.  Pediatr Dermatol. 1999;16(4):292-296
PubMed   |  Link to Article
von der Werth JM, Jemec GB. Morbidity in patients with hidradenitis suppurativa.  Br J Dermatol. 2001;144(4):809-813
PubMed   |  Link to Article
Jemec GB. Clinical practice: hidradenitis suppurativa.  N Engl J Med. 2012;366(2):158-164
PubMed   |  Link to Article
Mortimer PS, Dawber RP, Gales MA, Moore RA. Mediation of hidradenitis suppurativa by androgens.  Br Med J (Clin Res Ed). 1986;292(6515):245-248
PubMed   |  Link to Article
Barth JH, Layton AM, Cunliffe WJ. Endocrine factors in pre- and postmenopausal women with hidradenitis suppurativa.  Br J Dermatol. 1996;134(6):1057-1059
PubMed   |  Link to Article
Mortimer PS, Dawber RP, Gales MA, Moore RA. A double-blind controlled cross-over trial of cyproterone acetate in females with hidradenitis suppurativa.  Br J Dermatol. 1986;115(3):263-268
PubMed   |  Link to Article
Sawers RS, Randall VA, Ebling FJ. Control of hidradenitis suppurativa in women using combined antiandrogen (cyproterone acetate) and oestrogen therapy.  Br J Dermatol. 1986;115(3):269-274
PubMed   |  Link to Article
Joseph MA, Jayaseelan E, Ganapathi B, Stephen J. Hidradenitis suppurativa treated with finasteride.  J Dermatolog Treat. 2005;16(2):75-78
PubMed   |  Link to Article
Kraft JN, Searles GE. Hidradenitis suppurativa in 64 female patients: retrospective study comparing oral antibiotics and antiandrogen therapy.  J Cutan Med Surg. 2007;11(4):125-131
PubMed
Eicheler W, Dreher M, Hoffmann R, Happle R, Aumüller G. Immunohistochemical evidence for differential distribution of 5 alpha-reductase isoenzymes in human skin.  Br J Dermatol. 1995;133(3):371-376
PubMed   |  Link to Article
Yu CC, Cook MG. Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands.  Br J Dermatol. 1990;122(6):763-769
PubMed   |  Link to Article
Attanoos RL, Appleton MA, Douglas-Jones AG. The pathogenesis of hidradenitis suppurativa: a closer look at apocrine and apoeccrine glands.  Br J Dermatol. 1995;133(2):254-258
PubMed   |  Link to Article
Roberts JL, Fiedler V, Imperato-McGinley J,  et al.  Clinical dose ranging studies with finasteride, a type 2 5α-reductase inhibitor, in men with male pattern hair loss.  J Am Acad Dermatol. 1999;41(4):555-563
PubMed
Kapoor A. Benign prostatic hyperplasia (BPH) management in the primary care setting.  Can J Urol. 2012;19(suppl 1):10-17
PubMed
Swiglo BA, Cosma M, Flynn DN,  et al.  Clinical review: antiandrogens for the treatment of hirsutism: a systematic review and meta-analyses of randomized controlled trials [published online February 5, 2008].  J Clin Endocrinol Metab. 2008;93(4):1153-1160Link to Article
Link to Article
McClellan KJ, Markham A. Finasteride: a review of its use in male pattern hair loss.  Drugs. 1999;57(1):111-126
PubMed   |  Link to Article
Gonzalez ME, Cantatore-Francis J, Orlow SJ. Androgenetic alopecia in the paediatric population: a retrospective review of 57 patients.  Br J Dermatol. 2010;163(2):378-385
PubMed   |  Link to Article
Farrell AM, Randall VA, Vafaee T, Dawber RPR. Finasteride as a therapy for hidradenitis suppurativa.  Br J Dermatol. 1999;141(6):1138-1139
PubMed   |  Link to Article
Amory JK, Wang C, Swerdloff RS,  et al.  The effect of 5α-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.  J Clin Endocrinol Metab. 2007;92(5):1659-1665
PubMed   |  Link to Article
Collodel G, Scapigliati G, Moretti E. Spermatozoa and chronic treatment with finasteride: a TEM and FISH study.  Arch Androl. 2007;53(4):229-233
PubMed   |  Link to Article
Liu KE, Binsaleh S, Lo KC, Jarvi K. Propecia-induced spermatogenic failure: a report of two cases [published online December 11, 2007]. Fertil Steril. 2012;90(3):849.e17-849.e19. doi:10.1016/j.fertnstert.2007.08.026
 Propecia (finasteride). Food and Drug Administration website. http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020788s018lbl.pdf. Issued December 2010. Accessed January 1, 2013

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. At initial presentation, patient 3 had multiple inflammatory erythematous nodules on both inner thighs.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Patient 3 had tender erythematous nodules in the perianal region at presentation.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 3. After 3 years of finasteride therapy, patient 3 showed significant resolution of active disease, with a decrease in inflammatory nodules and residual scarring and dyspigmentation on the inner thighs.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 4. Patient 3 had residual scarring and dyspigmentation in the perianal area after 3 years of finasteride therapy.

Tables

References

Slade DE, Powell BW, Mortimer PS. Hidradenitis suppurativa: pathogenesis and management.  Br J Plast Surg. 2003;56(5):451-461
PubMed   |  Link to Article
Palmer RA, Keefe M. Early-onset hidradenitis suppurativa.  Clin Exp Dermatol. 2001;26(6):501-503
PubMed   |  Link to Article
Jourdain JC, Le Lorier B, Mourier C, Ploussard JP, Roussel F. Virilisation par deficit en 21-hydroxylase et hyperplasie sudorale axillaire.  Ann Dermatol Venereol. 1988;115(11):1136-1138
PubMed
Lewis F, Messenger AG, Wales JKH. Hidradenitis suppurativa as a presenting feature of premature adrenarche.  Br J Dermatol. 1993;129(4):447-448
PubMed   |  Link to Article
Mengesha YM, Holcombe TC, Hansen RC. Prepubertal hidradenitis suppurativa: two case reports and review of the literature.  Pediatr Dermatol. 1999;16(4):292-296
PubMed   |  Link to Article
von der Werth JM, Jemec GB. Morbidity in patients with hidradenitis suppurativa.  Br J Dermatol. 2001;144(4):809-813
PubMed   |  Link to Article
Jemec GB. Clinical practice: hidradenitis suppurativa.  N Engl J Med. 2012;366(2):158-164
PubMed   |  Link to Article
Mortimer PS, Dawber RP, Gales MA, Moore RA. Mediation of hidradenitis suppurativa by androgens.  Br Med J (Clin Res Ed). 1986;292(6515):245-248
PubMed   |  Link to Article
Barth JH, Layton AM, Cunliffe WJ. Endocrine factors in pre- and postmenopausal women with hidradenitis suppurativa.  Br J Dermatol. 1996;134(6):1057-1059
PubMed   |  Link to Article
Mortimer PS, Dawber RP, Gales MA, Moore RA. A double-blind controlled cross-over trial of cyproterone acetate in females with hidradenitis suppurativa.  Br J Dermatol. 1986;115(3):263-268
PubMed   |  Link to Article
Sawers RS, Randall VA, Ebling FJ. Control of hidradenitis suppurativa in women using combined antiandrogen (cyproterone acetate) and oestrogen therapy.  Br J Dermatol. 1986;115(3):269-274
PubMed   |  Link to Article
Joseph MA, Jayaseelan E, Ganapathi B, Stephen J. Hidradenitis suppurativa treated with finasteride.  J Dermatolog Treat. 2005;16(2):75-78
PubMed   |  Link to Article
Kraft JN, Searles GE. Hidradenitis suppurativa in 64 female patients: retrospective study comparing oral antibiotics and antiandrogen therapy.  J Cutan Med Surg. 2007;11(4):125-131
PubMed
Eicheler W, Dreher M, Hoffmann R, Happle R, Aumüller G. Immunohistochemical evidence for differential distribution of 5 alpha-reductase isoenzymes in human skin.  Br J Dermatol. 1995;133(3):371-376
PubMed   |  Link to Article
Yu CC, Cook MG. Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands.  Br J Dermatol. 1990;122(6):763-769
PubMed   |  Link to Article
Attanoos RL, Appleton MA, Douglas-Jones AG. The pathogenesis of hidradenitis suppurativa: a closer look at apocrine and apoeccrine glands.  Br J Dermatol. 1995;133(2):254-258
PubMed   |  Link to Article
Roberts JL, Fiedler V, Imperato-McGinley J,  et al.  Clinical dose ranging studies with finasteride, a type 2 5α-reductase inhibitor, in men with male pattern hair loss.  J Am Acad Dermatol. 1999;41(4):555-563
PubMed
Kapoor A. Benign prostatic hyperplasia (BPH) management in the primary care setting.  Can J Urol. 2012;19(suppl 1):10-17
PubMed
Swiglo BA, Cosma M, Flynn DN,  et al.  Clinical review: antiandrogens for the treatment of hirsutism: a systematic review and meta-analyses of randomized controlled trials [published online February 5, 2008].  J Clin Endocrinol Metab. 2008;93(4):1153-1160Link to Article
Link to Article
McClellan KJ, Markham A. Finasteride: a review of its use in male pattern hair loss.  Drugs. 1999;57(1):111-126
PubMed   |  Link to Article
Gonzalez ME, Cantatore-Francis J, Orlow SJ. Androgenetic alopecia in the paediatric population: a retrospective review of 57 patients.  Br J Dermatol. 2010;163(2):378-385
PubMed   |  Link to Article
Farrell AM, Randall VA, Vafaee T, Dawber RPR. Finasteride as a therapy for hidradenitis suppurativa.  Br J Dermatol. 1999;141(6):1138-1139
PubMed   |  Link to Article
Amory JK, Wang C, Swerdloff RS,  et al.  The effect of 5α-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.  J Clin Endocrinol Metab. 2007;92(5):1659-1665
PubMed   |  Link to Article
Collodel G, Scapigliati G, Moretti E. Spermatozoa and chronic treatment with finasteride: a TEM and FISH study.  Arch Androl. 2007;53(4):229-233
PubMed   |  Link to Article
Liu KE, Binsaleh S, Lo KC, Jarvi K. Propecia-induced spermatogenic failure: a report of two cases [published online December 11, 2007]. Fertil Steril. 2012;90(3):849.e17-849.e19. doi:10.1016/j.fertnstert.2007.08.026
 Propecia (finasteride). Food and Drug Administration website. http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020788s018lbl.pdf. Issued December 2010. Accessed January 1, 2013

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