Correspondence |

A Case Report of Bullous Pemphigoid Induced by Dipeptidyl Peptidase-4 Inhibitors

Iman Aouidad, MD; Charlotte Fite, MD; Eduardo Marinho, MD; Lydia Deschamps, MD; Beatrice Crickx, MD; Vincent Descamps, MD, PhD
JAMA Dermatol. 2013;149(2):243-245. doi:10.1001/jamadermatol.2013.1073.
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Cases of drug-induced bullous pemphigoid (BP) have been reported in association with spironolactone, furosemide, chloroquine, β-blocker, or antibiotic treatment.1,2 We report the case of a patient who developed a severe BP after starting therapy with a dipeptidyl peptidase-4 (DPP-4) inhibitor (vildagliptin), an incretin-based drug used to treat type 2 diabetes mellitus.

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Figure 1. Disseminated hemorrhagic bullae over an erythematous base.

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Figure 2. Direct immunofluorescence showing a linear deposit of IgG and C3 at the basement membrane zone.




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