We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
The Cutting Edge: Challenges in Medical and Surgical Therapies |

Topical Amitriptyline-Ketamine for the Treatment of Brachioradial Pruritus

Timothy J. Poterucha, BS; Sinead L. Murphy; Mark D. P. Davis, MD; Paola Sandroni, MD, PhD; Richard H. Rho, MD; Roger A. Warndahl, RPh; William T. Weiss, RPh
JAMA Dermatol. 2013;149(2):148-150. doi:10.1001/2013.jamadermatol.646.
Text Size: A A A
Published online


Brachioradial pruritus is a neuropathic itching condition that is characterized by unilateral or bilateral upper extremity itching. Herein, we report a case of brachioradial pruritus that was refractory to multiple other treatments but was completely relieved with the use of topical amitriptyline-ketamine.

Correspondence: Mark D. P. Davis, MD, Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (davis.mark2@mayo.edu).

Accepted for Publication: August 17, 2012.

Author Contributions: Mr Poterucha and Dr Davis had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Poterucha, Davis, Sandroni, and Weiss. Acquisition of data: Poterucha, Murphy, Davis, and Warndahl. Analysis and interpretation of data: Poterucha, Murphy, Davis, Sandroni, Rho, and Weiss. Drafting of the manuscript: Poterucha, Murphy, and Davis. Critical revision of the manuscript for important intellectual content: Poterucha, Murphy, Davis, Sandroni, Rho, Warndahl, and Weiss. Administrative, technical, and material support: Warndahl. Study supervision: Davis, Sandroni, and Weiss.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported in part by internal Mayo Clinic Department of Dermatology funds.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

6 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles