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The Cutting Edge: Challenges in Medical and Surgical Therapies | Feb 2013

Topical Amitriptyline-Ketamine for the Treatment of Brachioradial Pruritus

Timothy J. Poterucha, BS; Sinead L. Murphy; Mark D. P. Davis, MD; Paola Sandroni, MD, PhD; Richard H. Rho, MD; Roger A. Warndahl, RPh; William T. Weiss, RPh

JAMA Dermatol. 2013;149(2):148-150. doi:10.1001/2013.jamadermatol.646.

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Brachioradial pruritus is a neuropathic itching condition that is characterized by unilateral or bilateral upper extremity itching. Herein, we report a case of brachioradial pruritus that was refractory to multiple other treatments but was completely relieved with the use of topical amitriptyline-ketamine.

Correspondence: Mark D. P. Davis, MD, Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (davis.mark2@mayo.edu).

Accepted for Publication: August 17, 2012.

Author Contributions: Mr Poterucha and Dr Davis had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Poterucha, Davis, Sandroni, and Weiss. Acquisition of data: Poterucha, Murphy, Davis, and Warndahl. Analysis and interpretation of data: Poterucha, Murphy, Davis, Sandroni, Rho, and Weiss. Drafting of the manuscript: Poterucha, Murphy, and Davis. Critical revision of the manuscript for important intellectual content: Poterucha, Murphy, Davis, Sandroni, Rho, Warndahl, and Weiss. Administrative, technical, and material support: Warndahl. Study supervision: Davis, Sandroni, and Weiss.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported in part by internal Mayo Clinic Department of Dermatology funds.

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Poterucha TJ, Murphy SL, Davis MP, et al. Topical Amitriptyline-Ketamine for the Treatment of Brachioradial Pruritus. JAMA Dermatol. 2013;149(2):148-150. doi:10.1001/2013.jamadermatol.646.

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