0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
The Best of the Best |

Top-Accessed Article: Topical Rapamycin FREE

Anita N. Haggstrom, MD; Stephen E. Wolverton, MD
[+] Author Affiliations

Author Affiliations: Department of Dermatology, Indiana University School of Medicine, Indianapolis.


JAMA Dermatol. 2013;149(2):203. doi:10.1001/jamadermatol.2013.750.
Text Size: A A A
Published online

Haemel AK, O'Brian AL, Teng JM. Topical rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis. Arch Dermatol. 2010;146(7):715-718.

Recent success using mTOR (mammalian target of rapamycin) inhibitors such as rapamycin for the systemic manifestations of tuberous sclerosis exemplify how targeted therapy can treat genetic disorders. Haemel and colleagues describe the novel use of topical rapamycin in a petrolatum vehicle for facial angiofibromas in a patient with tuberous sclerosis. Since its publication, several authors have similarly reported successfully using various compounds of rapamycin or even the topical application of the commercially available oral solution for facial angiofibromas. Topical application of the oral solution is associated with local irritation that necessitates topical steroids. Compounded rapamycin is at least 10-fold more expensive than a similar amount of the oral solution. Rapamycin therapy is expensive, but the cost must be compared with alternative therapies, including pulsed dye or ablative lasers, that often require general anesthesia in this population. Prospective studies are needed to clarify the pharmocokinetics of topically applied rapamycin and the optimal formulation, dosing, duration, monitoring, and safety of this therapy.

From October 2010 to August 2011, this article was accessed 1676 times on the Archives of Dermatology website.

ARTICLE INFORMATION

Contact Dr Wolverton at the Department of Dermatology, Indiana University School of Medicine, 550 N University Blvd, Ste 3240, Indianapolis, IN 46202 (swolvert@iupui.edu).

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Topics