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Observation |

Giant Cellulitis-like Sweet Syndrome, a New Variant of Neutrophilic Dermatosis FREE

Andre M. Surovy, MD; Nedzmidin Pelivani, MD; Ivan Hegyi, MD; Urs Buettiker, MD; Helmut Beltraminelli, MD; Luca Borradori, MD
[+] Author Affiliations

Author Affiliations: Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.


JAMA Dermatol. 2013;149(1):79-83. doi:10.1001/2013.jamadermatol.548.
Text Size: A A A
Published online

Background Neutrophilic dermatoses comprise a wide spectrum of inflammatory diseases with overlapping features characterized histologically by the presence of an aseptic neutrophilic infiltrate in the epidermis, dermis, and/or hypodermis and are often associated with systemic inflammatory and neoplastic disorders.

Observations We describe 3 patients with an unusual neutrophilic dermatosis characterized by relapsing episodes of fever, widespread infiltrated plaques with bullous appearance, and variable involvement of the arms, legs, abdomen, and/or trunk. Light microscopy studies showed marked edema of the papillary dermis with an inflammatory infiltrate consisting mainly of mature neutrophils. All 3 patients were morbidly obese, and workup revealed underlying cancer in 2 cases: myeloma and breast carcinoma. Management of the underlying disease resulted in long-term remission of the skin disease.

Conclusions The clinicopathologic features in our 3 cases best correspond to a widespread giant cellulitis-like form of Sweet syndrome. Knowledge of this newly observed unusual variant of Sweet syndrome within the broad spectrum of neutrophilic diseases is important for its prompt and proper management.

Figures in this Article

Neutrophilic dermatoses comprise a wide spectrum of diseases, including Sneddon-Wilkinson disease (subcorneal pustulosis), Sweet syndrome (acute febrile neutrophilic dermatosis), pyoderma gangrenosum, erythema elevatum et diutinum, eccrine neutrophilic hidradenitis, and neutrophilic panniculitis.13 These disorders, characterized histologically by the presence of an aseptic neutrophilic infiltrate in the epidermis, dermis, and/or hypodermis, frequently show overlapping features.1,4 Neutrophilic dermatoses are commonly associated with systemic inflammatory and neoplastic disorders, including Crohn disease, rheumatoid arthritis, and hematologic malignant neoplasms.13 Neutrophilic dermatoses have been increasingly associated with extracutaneous neutrophilic infiltrates: lung, articular, skeletal, liver, spleen, lymph node, ocular, and gastrointestinal involvement have been described. On the basis of these observations, the term neutrophilic diseases has been proposed.1,2

Sweet syndrome is characterized by the sudden development of tender inflammatory cutaneous lesions, abundant dermal neutrophilic inflammatory infiltrate evident on histopathologic examination, as well as an increase of inflammatory markers in the blood.49

We report 3 cases of a novel neutrophilic dermatosis bearing a resemblance to Sweet syndrome that is unusual for the development of giant widespread infiltrated inflammatory plaques.

CASE 1

A 62-year-old man developed painful erythematous plaques involving his left leg, buttocks, and trunk as well as fever and malaise. During the preceding 2 years, the patient had experienced 8 similar episodes of variable intensity, which regressed spontaneously within 4 weeks. There had been no drug therapy preceding these episodes. On examination, he had an extensive erythematous infiltrated plaque involving the left lower leg, more than 60 cm in diameter. The lesion was sharply delimited, warm, and strongly infiltrated with a vesicular or bullous appearance. Purpuric lesions were also pres ent. In addition, the patient exhibited discrete, erythematous, slightly infiltrated plaques of up to 50 cm in diameter on the thighs, trunk, and buttocks (Figure 1). He was obese, with a body mass index of 51 (calculated as weight in kilograms divided by height in meters squared). Light microscopy studies of a biopsy specimen revealed marked edema of the papillary dermis with an inflammatory infiltrate of the upper dermis consisting mainly of mature neutrophils. There was no evidence of leukocytoclastic vasculitis. Periodic acid–Schiff and Ziehl-Neelsen stains were negative for fungi and mycobacteria, respectively. Direct immunofluorescence microscopy study results also were negative. A complete blood cell count showed leukocytosis (white blood cells, 10 600/μL [to convert to ×109/L, multiply by 0.001]) and a platelet count of 96 000 × 103/μL (1:1 conversion to ×109/L). The C-reactive protein level was 279 mg/L (reference, <5 mg/L; to convert to nanomoles per liter, multiply by 0.9524). Electrolyte levels and results of renal and hepatic function tests were within normal limits. Bacteriologic examinations and repeated cultures of wound swabs did not yield any growth of bacteria. Testing for antinuclear antibodies was negative. Serum electrophoresis with immunofixation showed hypergammaglobulinemia and presence of free light chains type λ and κ; free light chains type λ were detected in the urine. A bone marrow aspirate and bone marrow biopsy specimen revealed a significant increase of the plasma cells up to 40%. Findings of thoracoabdominal computed tomography were normal, and a diagnosis of multiple myeloma stage IA was made.

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Graphic Jump Location

Figure 1. Lesions associated with Sweet syndrome in patient 1. A, Erythematous infiltrated plaque with a bullous appearance involving the left leg. B, Erythematous, slightly infiltrated plaques on the abdomen. C, Similar lesions on the back and buttocks.

Therapy was initiated with amoxicillin/clavulanic and dalacin acid, with no effect on the cutaneous lesions after 1 week. However, after review of the patient's clinical history and the new findings, he was given prednisone, 1 mg/kg/d, resulting in significant improvement of the skin lesions within 3 weeks. For treatment of multiple myeloma, the patient underwent a cycle including melphalan hydrochloride and prednisolone, resulting in remission. During the 12-month follow-up, the patient had no recurrence of his skin lesions.

CASE 2

A 48-year-old woman developed skin lesions on her legs associated with fever, with temperatures up to 39.5°C, and malaise. The patient had similar recurrent, self-resolving, painful skin lesions associated with fever during the past 8 years. On examination, the obese patient (body mass index, 46.8) had extensive sharply limited, painful, warm, and strongly infiltrated erythematous plaques on the right lower leg and knee as well as on the extensor side of her left arm, the buttocks, and the trunk. Some lesions had a bullous appearance with a purpuric component (Figure 2). Light microscopy revealed marked edema of the papillary dermis with a dense inflammatory infiltrate of the upper dermis consisting mainly of mature neutrophils without leukocytoclastic vasculitis (Figure 3). Periodic acid–Schiff and Ziehl-Neelsen staining results were negative for fungi and mycobacteria, respectively. Results of bacteriologic examination and culture of the wound smears, as well as direct immunofluorescence microscopy studies, also were negative. Laboratory examinations revealed leukocytosis (white blood cells, 24 000/μL) and high C-reactive protein levels (429 mg/L). Extensive workup did not find any evidence of an underlying solid tumor or lymphoproliferative disorder. The patient was given prednisone, 1 mg/kg/d, with dose reduction across several weeks. With this treatment, the cutaneous and systemic manifestations were controlled for 7 months, when the patient suddenly died of myocardial infarction with heart failure.

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Graphic Jump Location

Figure 2. Lesions associated with Sweet syndrome in patient 2. A, Erythematous infiltrated plaques on the back and buttocks. B, Erythematous plaques with bullous appearance and a purpuric component. C, Plaque on the right thigh and the knee.

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Graphic Jump Location

Figure 3. Light microscopy and histologic examination results in patient 2. A, A dense inflammatory infiltrate of the upper dermis and middermis consists mainly of mature neutrophils and marked edema of the papillary dermis (hematoxylin-eosin, original magnification ×100). B, Neutrophils in perivascular distribution without leukocytoclasia and interstitial edema (hematoxylin-eosin, original magnification ×400).

CASE 3

A 68-year-old woman developed painful erythematous plaques on her right leg associated with temperatures up to 39°C and malaise. The patient had 3 similar episodes during a 3-month period. On examination, she had several extensive, sharply limited erythematous plaques more than 50 cm in diameter involving the suprapubic region and the right thigh, leg, and foot. Some lesions had a vesicular or bullous appearance as well as a purpuric component (Figure 4). Her body mass index was 35. Light microscopy revealed marked edema of the papillary dermis with a dense inflammatory infiltrate of the upper dermis consisting mainly of mature neutrophils without evidence of leukocytoclastic vasculitis. Periodic acid–Schiff and Ziehl-Neelsen staining results were negative for fungi and mycobacteria, respectively. The patient developed leukocytosis (white blood cells, 11 300/μL) with a C-reactive protein level increased to 235 mg/L. Bacteriologic examinations and repeated cultures of the wound swabs or tissue samples did not yield any bacteria or fungi. No monoclonal immunoglobulin was detected by immunofixation. Topical corticosteroid therapy was started, with a transient improvement followed by a relapse. On reevaluation at that time, breast carcinoma was diagnosed. After surgical removal of the tumor, the patient did not develop any further skin lesions during the 12-month follow-up.

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Graphic Jump Location

Figure 4. Large erythematous infiltrated plaques involving the hip region, the right leg, and the right foot in patient 3.

Our 3 patients developed severe relapsing eruptions with giant inflammatory lesions ranging from erythematous, slightly infiltrated lesions to painful indurated plaques with vesicular, bullous, or even hemorrhagic appearance. Lesions developed asymmetrically on the legs or arms, trunk, abdomen, and face. Their size was impressive—up to 100 cm in diameter. Clinical and histopathologic features best fit the diagnosis of Sweet syndrome. Su and Liu5 first proposed a set of criteria for Sweet syndrome, which were subsequently revised.6 When the 2 major criteria and at least 2 of the 4 minor criteria are fulfilled, classic Sweet syndrome can be diagnosed. Our patients fulfilled the major criteria as well as 3 or 4 minor criteria. Search for an underlying associated disease disclosed, in 2 patients, cancer. Two patients responded promptly to systemic corticosteroids, and the third patient experienced improvement with high-potency topical corticosteroids. Finally, the disease went into remission in 2 patients after management of the underlying malignant disease, with no further recurrence.

In classic Sweet syndrome, lesions usually affect the head, neck, and upper extremities. Lesions may be single or multiple and consist of erythematous papules and plaques with a pseudovesicular appearance. The lesions may coalesce to form irregularly shaped plaques. Concomitant fever, with temperatures up to 39°C, occurs in as many as 80% to 90% of patients. The evolution of the syndrome is chronic and relapsing in up to one-third of the cases.4,5 As observed in 2 of our patients, the cutaneous eruption can resolve spontaneously without specific therapy. Malignancy-associated Sweet syndrome shows some distinctive features compared with idiopathic Sweet syndrome. Lesions in the malignancy-associated syndrome tend to have a more widespread distribution, including involvement of the lower limbs.1012 Furthermore, lesions tend to be more frequently bullous, hemorrhagic, and ulcerated and show some overlap with or bear close resemblance to pyoderma gangrenosum, as observed in our cases.1012 Anomalies of the blood cell count are found in 50% to 80% of cases,1012 as in our first patient. Such atypical features in Sweet syndrome should prompt the search for an associated undiagnosed cancer or for tumor recurrence in a patient with a history of cancer.1015 In 2 of our patients, dermatosis preceded the discovery of an underlying malignant neoplasm, either a solid tumor or a myeloproliferative disease.

Sweet syndrome is characterized histopathologically by the presence of a large nodular dermal infiltrate of mature neutrophils together with marked edema in the upper dermis. Fragmented nuclear “dust” of neutrophils (leukocytoclasia) in “top-heavy” fashion may be present, but the histologic signs of a primary leukocytoclastic vasculitis are absent.79 In the overlying epidermis, a variable degree of neutrophilic spongiosis or intraepidermal neutrophilic abscess formation can be occasionally observed. In our first patient with relapsing episodes, light microscopy revealed strong dermal edema with only mild neutrophilic infiltrate. Such images with few neutrophils have been described10 in cases of Sweet syndrome with chronic relapsing lesions. Noteworthy, in Sweet syndrome associated with hematologic malignant neoplasms, the infiltrate may also consist of immature myeloid or leukemic cells.16,17

In our review of the English-language literature, including major textbooks,14,15 we were unable to find a description of Sweet syndrome of similar extent as in our patients. The severe widespread, relapsing eruption made us consider the possibility of an as-yet unrecognized novel variant of Sweet syndrome associated with giant cellulitis-like plaques. Strikingly, all 3 patients were morbidly obese, with body mass index higher than 35, which may have favored the development of such giant lesions. Our cases differed from a newly described18 variant of Sweet syndrome mimicking necrotizing fasciitis. This report described 3 patients who were septic, had a hematologic malignant neoplasm, and developed a localized, tender, indurated erythematous-violaceous plaque after therapy with granulocyte colony-stimulating factor. The inflammatory infiltrate composed of neutrophils further extended into the deep soft tissue and the muscle. Several differential diagnoses were further discussed; the first was an acute infectious cellulitis. However, microbiologic analysis results of tissue smears and biopsy specimens, as well as blood cultures, remained sterile, and oral and intravenous broad-spectrum antibiotics had no effect. Nevertheless, triggering of Sweet syndrome and other neutrophilic diseases by bacteria and other infectious agentshas been reported.19 The workup of the patients also excluded autoimmune bullous skin disease, cutaneous lymphoma, and vasculitis. Finally, our patients did not have a family history or past evidence for aphthous stomatitis, arthritis, myalgias, serositis, or abdominal symptoms suggestive of a congenital autoinflammatory syndrome. Hence, the features were almost per exclusionem consistent with a neutrophilic disease.

Recognition and diagnosis of Sweet syndrome and other neutrophilic dermatoses is important not only in the search for underlying disease1,2,7,10 but also for the initiation of appropriate treatment.20 Controlled trials have not been conducted; however, clinical practice has shown the most effective therapy for Sweet syndrome to be oral prednisone, 0.5 to 1.0 mg/kg/d, for 4 to 6 weeks.8,18 When the lesions are few and localized, topical corticosteroids and calcineurin inhibitors may be tried. Potassium iodide, dapsone, and colchicine represent valuable first-line alternatives for treatment. Finally, indomethacin, clofazimine, and cyclosporine have been among therapies used.8,18

In conclusion, we describe a new variant of Sweet syndrome characterized by relapsing widespread giant lesions. The eruption invariably occurred in morbidly obese patients. It is likely that this giant cellulitis-like variant of Sweet syndrome is not so rare; rather, it has simply remained unreported or unrecognized.

Correspondence: Luca Borradori, MD, Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland (luca.borradori@insel.ch).

Accepted for Publication: July 26, 2012.

Author Contributions: Drs Pelivani, Hegyi, and Borradori had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Surovy and Pelivani contributed equally to the study. Study concept and design: Surovy, Pelivani, and Borradori. Acquisition of data: Surovy, Pelivani, and Buettiker. Analysis and interpretation of data: Surovy, Pelivani, Hegyi, Beltraminelli, and Borradori. Drafting of the manuscript: Surovy, Pelivani, Hegyi, Buettiker, and Borradori. Critical revision of the manuscript for important intellectual content: Pelivani, Beltraminelli, and Borradori. Statistical analysis: Surovy. Obtained funding: Surovy. Administrative, technical, and material support: Surovy, Hegyi, and Borradori. Study supervision: Pelivani, Buettiker, Beltraminelli, and Borradori.

Conflict of Interest Disclosures: None reported.

Additional Contributions: M. Fritz Schweizer, CPP, provided photographic work and support.

Wallach D. Neutrophilic dermatoses: an overview.  Clin Dermatol. 2000;18(3):229-231
PubMed   |  Link to Article
Callen JP. Neutrophilic dermatoses.  Dermatol Clin. 2002;20(3):409-419
PubMed   |  Link to Article
Wallach D, Vignon-Pennamen M-D. From acute febrile neutrophilic dermatosis to neutrophilic disease: forty years of clinical research.  J Am Acad Dermatol. 2006;55(6):1066-1071
PubMed   |  Link to Article
Sweet RD. An acute febrile neutrophilic dermatosis.  Br J Dermatol. 1964;76:349-356
PubMed   |  Link to Article
Su WP, Liu HN. Diagnostic criteria for Sweet's syndrome.  Cutis. 1986;37(3):167-174
PubMed
von den Driesch P. Sweet's syndrome (acute febrile neutrophilic dermatosis).  J Am Acad Dermatol. 1994;31(4):535-556
PubMed   |  Link to Article
Cohen PR, Kurzrock R. Sweet's syndrome: a neutrophilic dermatosis classically associated with acute onset and fever.  Clin Dermatol. 2000;18(3):265-282
PubMed   |  Link to Article
Cohen PR. Sweet's syndrome—a comprehensive review of an acute febrile neutrophilic dermatosis.  Orphanet J Rare Dis. 2007;2:34
PubMed  |  Link to Article   |  Link to Article
Yi S, Bhate C, Schwartz RA. Sweet's syndrome: an update and review.  G Ital Dermatol Venereol. 2009;144(5):603-612
PubMed
Cohen PR, Talpaz M, Kurzrock R. Malignancy-associated Sweet's syndrome: review of the world literature.  J Clin Oncol. 1988;6(12):1887-1897
PubMed
Cohen PR, Kurzrock R. Sweet's syndrome and cancer.  Clin Dermatol. 1993;11(1):149-157
PubMed   |  Link to Article
Bayer-Garner IB, Cottler-Fox M, Smoller BR. Sweet syndrome in multiple myeloma: a series of six cases.  J Cutan Pathol. 2003;30(4):261-264
PubMed   |  Link to Article
Walling HW, Snipes CJ, Gerami P, Piette WW. The relationship between neutrophilic dermatosis of the dorsal hands and Sweet syndrome: report of 9 cases and comparison to atypical pyoderma gangrenosum.  Arch Dermatol. 2006;142(1):57-63
PubMed   |  Link to Article
Barham KL, Jorizzo JL, Grattan B, Cox NH. Vasculitis and neutrophilic vascular reactions. In: Bolognia JL, Jorizzo JL, Rapini RP, et al, eds. Dermatology. Vol 1. 2nd ed. St Louis, MO: Mosby; 2008:380-383
Moschella SL, Davis MDP. Sweet's syndrome. In: Burns T, Breathnach S, Cox N, Griffiths CH, eds. Rook's Textbook of Dermatology. 7th ed. Oxford, UK: Blackwell Science Ltd; 2004:33-36
Requena L, Kutzner H, Palmedo G,  et al.  Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes.  Arch Dermatol. 2005;141(7):834-842
PubMed   |  Link to Article
Hünermund A, Wendel AM, Geissinger E, Bröcker EB, Stoevesandt J. Typically atypical: histiocytoid Sweet's syndrome, associated with malignancy [in German].  J Dtsch Dermatol Ges. 2011;9(9):666-669
PubMed
Kroshinsky D, Alloo A, Rothschild B,  et al.  Necrotizing Sweet syndrome: a new variant of neutrophilic dermatosis mimicking necrotizing fasciitis [published online March 27, 2012].  J Am Acad Dermatol
PubMed  |  Link to Article
Dinh H, Murugasu A, Gin D. Sweet's syndrome associated with cellulitis.  Australas J Dermatol. 2007;48(2):105-109
PubMed   |  Link to Article
Cohen PR. Neutrophilic dermatoses: a review of current treatment options.  Am J Clin Dermatol. 2009;10(5):301-312
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. Lesions associated with Sweet syndrome in patient 1. A, Erythematous infiltrated plaque with a bullous appearance involving the left leg. B, Erythematous, slightly infiltrated plaques on the abdomen. C, Similar lesions on the back and buttocks.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Lesions associated with Sweet syndrome in patient 2. A, Erythematous infiltrated plaques on the back and buttocks. B, Erythematous plaques with bullous appearance and a purpuric component. C, Plaque on the right thigh and the knee.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 3. Light microscopy and histologic examination results in patient 2. A, A dense inflammatory infiltrate of the upper dermis and middermis consists mainly of mature neutrophils and marked edema of the papillary dermis (hematoxylin-eosin, original magnification ×100). B, Neutrophils in perivascular distribution without leukocytoclasia and interstitial edema (hematoxylin-eosin, original magnification ×400).

Place holder to copy figure label and caption
Graphic Jump Location

Figure 4. Large erythematous infiltrated plaques involving the hip region, the right leg, and the right foot in patient 3.

Tables

References

Wallach D. Neutrophilic dermatoses: an overview.  Clin Dermatol. 2000;18(3):229-231
PubMed   |  Link to Article
Callen JP. Neutrophilic dermatoses.  Dermatol Clin. 2002;20(3):409-419
PubMed   |  Link to Article
Wallach D, Vignon-Pennamen M-D. From acute febrile neutrophilic dermatosis to neutrophilic disease: forty years of clinical research.  J Am Acad Dermatol. 2006;55(6):1066-1071
PubMed   |  Link to Article
Sweet RD. An acute febrile neutrophilic dermatosis.  Br J Dermatol. 1964;76:349-356
PubMed   |  Link to Article
Su WP, Liu HN. Diagnostic criteria for Sweet's syndrome.  Cutis. 1986;37(3):167-174
PubMed
von den Driesch P. Sweet's syndrome (acute febrile neutrophilic dermatosis).  J Am Acad Dermatol. 1994;31(4):535-556
PubMed   |  Link to Article
Cohen PR, Kurzrock R. Sweet's syndrome: a neutrophilic dermatosis classically associated with acute onset and fever.  Clin Dermatol. 2000;18(3):265-282
PubMed   |  Link to Article
Cohen PR. Sweet's syndrome—a comprehensive review of an acute febrile neutrophilic dermatosis.  Orphanet J Rare Dis. 2007;2:34
PubMed  |  Link to Article   |  Link to Article
Yi S, Bhate C, Schwartz RA. Sweet's syndrome: an update and review.  G Ital Dermatol Venereol. 2009;144(5):603-612
PubMed
Cohen PR, Talpaz M, Kurzrock R. Malignancy-associated Sweet's syndrome: review of the world literature.  J Clin Oncol. 1988;6(12):1887-1897
PubMed
Cohen PR, Kurzrock R. Sweet's syndrome and cancer.  Clin Dermatol. 1993;11(1):149-157
PubMed   |  Link to Article
Bayer-Garner IB, Cottler-Fox M, Smoller BR. Sweet syndrome in multiple myeloma: a series of six cases.  J Cutan Pathol. 2003;30(4):261-264
PubMed   |  Link to Article
Walling HW, Snipes CJ, Gerami P, Piette WW. The relationship between neutrophilic dermatosis of the dorsal hands and Sweet syndrome: report of 9 cases and comparison to atypical pyoderma gangrenosum.  Arch Dermatol. 2006;142(1):57-63
PubMed   |  Link to Article
Barham KL, Jorizzo JL, Grattan B, Cox NH. Vasculitis and neutrophilic vascular reactions. In: Bolognia JL, Jorizzo JL, Rapini RP, et al, eds. Dermatology. Vol 1. 2nd ed. St Louis, MO: Mosby; 2008:380-383
Moschella SL, Davis MDP. Sweet's syndrome. In: Burns T, Breathnach S, Cox N, Griffiths CH, eds. Rook's Textbook of Dermatology. 7th ed. Oxford, UK: Blackwell Science Ltd; 2004:33-36
Requena L, Kutzner H, Palmedo G,  et al.  Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes.  Arch Dermatol. 2005;141(7):834-842
PubMed   |  Link to Article
Hünermund A, Wendel AM, Geissinger E, Bröcker EB, Stoevesandt J. Typically atypical: histiocytoid Sweet's syndrome, associated with malignancy [in German].  J Dtsch Dermatol Ges. 2011;9(9):666-669
PubMed
Kroshinsky D, Alloo A, Rothschild B,  et al.  Necrotizing Sweet syndrome: a new variant of neutrophilic dermatosis mimicking necrotizing fasciitis [published online March 27, 2012].  J Am Acad Dermatol
PubMed  |  Link to Article
Dinh H, Murugasu A, Gin D. Sweet's syndrome associated with cellulitis.  Australas J Dermatol. 2007;48(2):105-109
PubMed   |  Link to Article
Cohen PR. Neutrophilic dermatoses: a review of current treatment options.  Am J Clin Dermatol. 2009;10(5):301-312
PubMed   |  Link to Article

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