Correspondence |

Levetiracetam: A Possible New Inducer of Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome in 2 Cases

Tu Anh Duong, MD; Cynthia Haddad, PharmD; Laurence Valeyrie-Allanore, MD; Emilie Sbidian, MD; Olivier Chosidow, MD, PhD; Pierre Wolkenstein, MD, PhD
JAMA Dermatol. 2013;149(1):113-115. doi:10.1001/2013.jamadermatol.266.
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On January 31, 2011, the US Food and Drug and Administration (FDA) registered levetiracetam (LV) on the list of drugs under safety monitoring for the risk of Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN).1 Chemically unrelated to aromatic acid antiepileptic drugs, LV is considered a “safe” alternative for patients with previous severe cutaneous adverse reaction (SCAR).2 Herein we describe 2 cases of TEN for which the FDA alert prompted the LV causality suspicion. Drug causality was assessed using the specific Algorithm of Drug Causality for Epidermal Necrolysis (ALDEN), the Naranjo method, and the French Pharmacovigilance (FPV) method.3,4

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