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The Cutting Edge: Challenges in Medical and Surgical Therapies | Jan 2013

Intralesional Adalimumab for the Treatment of Refractory Balanitis Xerotica Obliterans

Elie B. Lowenstein, MD; Joshua A. Zeichner, MD

JAMA Dermatol. 2013;149(1):23-24. doi:10.1001/2013.jamadermatol.39.

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Balanitis xerotica obliterans (BXO) is a form of lichen sclerosus (LS) that affects the penis. This autoimmune inflammatory disorder can lead to significant morbidity because of scarring and urinary and sexual discomfort.

Correspondence: Dr Zeichner, Department of Dermatology, Mount Sinai Medical Center, 5 E 98th St, 5th Floor, New York, NY 10029 (joshua.zeichner@mssm.edu).

Accepted for Publication: July 24, 2012.

Author Contributions: Both authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Lowenstein and Zeichner. Acquisition of data: Lowenstein and Zeichner. Analysis and interpretation of data: Lowenstein and Zeichner. Drafting of the manuscript: Lowenstein and Zeichner. Critical revision of the manuscript for important intellectual content: Lowenstein and Zeichner. Administrative, technical, and material support: Lowenstein. Study supervision: Zeichner.

Conflict of Interest Disclosures: None reported.

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Figure 1. Erosions, crusting, and atrophic scarring of the shaft and coronal sulcus before treatment.

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Figure 2. After 4 weeks of treatment, there is nearly complete healing, with only a single 0.5-cm atrophic patch remaining on the penile shaft.

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Lowenstein EB, Zeichner JA. Intralesional Adalimumab for the Treatment of Refractory Balanitis Xerotica Obliterans. JAMA Dermatol. 2013;149(1):23-24. doi:10.1001/2013.jamadermatol.39.

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