The Cutting Edge: Challenges in Medical and Surgical Therapies |

Intralesional Adalimumab for the Treatment of Refractory Balanitis Xerotica Obliterans

Elie B. Lowenstein, MD; Joshua A. Zeichner, MD
JAMA Dermatol. 2013;149(1):23-24. doi:10.1001/2013.jamadermatol.39.
Text Size: A A A
Published online


Balanitis xerotica obliterans (BXO) is a form of lichen sclerosus (LS) that affects the penis. This autoimmune inflammatory disorder can lead to significant morbidity because of scarring and urinary and sexual discomfort.

Correspondence: Dr Zeichner, Department of Dermatology, Mount Sinai Medical Center, 5 E 98th St, 5th Floor, New York, NY 10029 (joshua.zeichner@mssm.edu).

Accepted for Publication: July 24, 2012.

Author Contributions: Both authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Lowenstein and Zeichner. Acquisition of data: Lowenstein and Zeichner. Analysis and interpretation of data: Lowenstein and Zeichner. Drafting of the manuscript: Lowenstein and Zeichner. Critical revision of the manuscript for important intellectual content: Lowenstein and Zeichner. Administrative, technical, and material support: Lowenstein. Study supervision: Zeichner.

Conflict of Interest Disclosures: None reported.

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. Erosions, crusting, and atrophic scarring of the shaft and coronal sulcus before treatment.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. After 4 weeks of treatment, there is nearly complete healing, with only a single 0.5-cm atrophic patch remaining on the penile shaft.




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles