Correspondence |

Hidradenitis Suppurativa, Eruptive Melanocytic Nevi, and Keratosis Pilaris–like Eruption in a Patient Treated With Vemurafenib

Liqiao Ma, BS; Arturo R. Dominguez, MD; George R. Collins, DO; Kevin F. Kia, MD; Clay J. Cockerell, MD
Arch Dermatol. 2012;148(12):1428-1429. doi:10.1001/2013.jamadermatol.23.
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We report a case of hidradenitis suppurativa and eruptive melanocytic nevi associated with a keratosis pilaris (KP)-like eruption from vemurafenib, lending further insight into keratinocyte differentiation and melanocyte proliferation pathways.

Correspondence: Dr Kia, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 (kevinfkia@gmail.com).

Conflict of Interest Disclosures: None reported.

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Figure 1. Clinical images of our vemurafenib-treated patient. A and B, After vemurafenib treatment began, the patient developed diffuse open comedones on the scalp (A) and nodules and multiheaded comedones on the axilla (B). C, The scalp lesions resolved 6 weeks after vemurafenib therapy was discontinued.

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Figure 2. Biopsy specimens from our vemurafenib-treated patient (hematoxylin-eosin, original magnification ×40). Biopsy specimens from the scalp and postauricular skin showed (A) follicular plugging and epidermal hyperkeratosis with (B) small cystically dilated open comedones without nodular solar elastosis or other dermal degenerative changes. Patchy, superficial dermal perivascular chronic lymphohistiocytic inflammation was also apparent.




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