In this article, Travis and colleagues report 3 cases of vitiligo that were successfully treated with tacrolimus ointment. Although the number of cases is small, this report is notable because it describes patients with disease that was refractory to treatment with both topical corticosteroids and phototherapy, mainstays of therapy for vitiligo. Tacrolimus ointment was well tolerated in these patients, with no local adverse effects. It is an excellent alternative to topical corticosteroid therapy for vitiligo, especially in the face and intertriginous areas, where the risk of steroid atrophy is of major concern, and can also be used in areas that are not easily accessible to phototherapy. It is well tolerated in both children and adults.