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Rapid Healing of Scar-Associated Chronic Wounds After Ablative Fractional Resurfacing

Peter R. Shumaker, MD; Julia M. Kwan, MD; Evangelos V. Badiavas, MD, PhD; Jill Waibel, MD; Stephen Davis, BS; Nathan S. Uebelhoer, DO
Arch Dermatol. 2012;148(11):1289-1293. doi:10.1001/2013.jamadermatol.256.
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Background  Skin compromised by traumatic scars and contractures can manifest decreased resistance to shearing and other forces, while increased tension and skin fragility contribute to chronic erosions and ulcerations. Chronic wounds possess inflammatory mediator profiles and other characteristics, such as the presence of biofilms, that can inhibit healing.

Observations  Three patients with multiple traumatic scars related to blast injuries initiated a course of ablative fractional laser therapy for potential mitigation of contractures, poor pliability, and textural irregularity. Patients also had chronic focal erosions or ulcerations despite professional wound care. All patients experienced incidental rapid healing of their chronic wounds within 2 weeks of their initial ablative fractional laser treatment. Healing was sustained throughout the treatment course and beyond and was associated with gradual enhancements in scar pliability, texture, durability, and range of motion.

Conclusions  The unique pattern of injury associated with ablative fractional laser treatment may have various potential wound-healing advantages. These advantages include the novel concept of photomicrodebridement, including biofilm disruption and the stimulation of de novo growth factor secretion and collagen remodeling. If confirmed, ablative fractional resurfacing could be a potent new addition to traditional wound and scar treatment paradigms.

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Grahic Jump Location

Figure. Photographs of a 26-year-old patient who underwent bilateral above-knee amputations. A, Approximately 5 months after injury, persistent focal erosions and ulcers are associated with a split-thickness skin graft on his right amputation stump. B, Significant interval healing is observed approximately 1 week after a single fractionated laser treatment. C, Approximately 2 months after a single fractionated laser treatment, almost complete reepithelialization is observed along with enhancements in texture, color, and pliability. A 2-mm erosion at the center of the graft was reportedly the result of trauma from the prosthetic device. Focal laser hair reduction was also performed. D, Cumulative and sustained improvements were observed 8 months after his initial treatment and 6 months after a second fractional laser treatment.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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