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Correspondence | Nov 2012

A Case of Multifocal Idiopathic Fibrosclerosis With Cutaneous Involvement

Elias E. Ayli, DO; Diya F. Mutasim, MD

Arch Dermatol. 2012;148(11):1335-1336. doi:10.1001/archdermatol.2012.2424.

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Multifocal idiopathic fibrosclerosis (MIF) is a rare disorder of unknown cause that presents with progressive fibrosis of multiple organ systems, most commonly the thyroid, mediastinum, retroperitoneum, and to a lesser degree the orbits, pancreas, and gallbladder.¹ However, to our knowledge, we report herein the first case of MIF with concomitant skin involvement.

Correspondence: Dr Mutasim, Department of Dermatology, University of Cincinnati College of Medicine, PO Box 670592, Cincinnati, Ohio 45267-0592 (diya.mutasim@uc.edu).

Conflict of Interest Disclosures: None reported.

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Figure 1. On the right chest, note the deeply indurated, telangiectatic, and violaceous smooth plaque.

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Figure 2. Hematoxylin-eosin–stained incisional biopsy specimen. A, Low magnification reveals marked fibrosis of the deep reticular dermis as well as a patchy and interstitial lymphoplasmacytic infiltrate (original magnification ×20). B, Higher magnification reveals diffuse sclerosis, a moderate interstitial infiltrate of lymphocytes and plasma cells, and marked concentric sclerosis around small blood vessels (original magnification ×100).

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Ayli EE, Mutasim DF. A Case of Multifocal Idiopathic Fibrosclerosis With Cutaneous Involvement. Arch Dermatol. 2012;148(11):1335-1336. doi:10.1001/archdermatol.2012.2424.

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