We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Paclitaxel-Induced Acral Erythema

Kristen N. Richards, MD, MS; Doina Ivan, MD; Rashid M. Rashid, MD, PhD; Susan Y. Chon, MD
Arch Dermatol. 2012;148(11):1333-1334. doi:10.1001/archdermatol.2012.2830.
Text Size: A A A
Published online


Paclitaxel is an antimicrotubule agent that is approved by the US Food and Drug Administration for the treatment of ovarian, breast, non–small cell lung carcinoma, and Kaposi's sarcoma.1 Despite the frequency of cutaneous adverse reactions observed with paclitaxel, only 3 reports of acral erythema24 have been published. Herein, we report a case of keratoderma-like acral erythema presenting in locations atypical for traditional acral erythema, including the dorsal aspects of the hands and feet. Each previously reported case of paclitaxel-induced acral erythema occurred in a similar distribution, suggesting that this acral erythema, while unusual, represents a unique presentation of a common adverse effect of chemotherapy.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. Right lateral foot with mild erythema and a central yellow plaque in a linear pattern.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Skin punch biopsy specimen from the right foot plaque. Epithelial acanthosis with prominent compact orthokeratotic hyperkeratosis and areas of parakeratosis are seen (hematoxylin-eosin, original magnification ×10).




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Paclitaxel-induced acral erythema. Arch Dermatol 2012;148(11):1333-4.
Management of Paclitaxel-induced hand-foot syndrome. Breast Care (Basel) 2013;8(3):215-7.