Correspondence |

Paclitaxel-Induced Acral Erythema

Kristen N. Richards, MD, MS; Doina Ivan, MD; Rashid M. Rashid, MD, PhD; Susan Y. Chon, MD
Arch Dermatol. 2012;148(11):1333-1334. doi:10.1001/archdermatol.2012.2830.
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Paclitaxel is an antimicrotubule agent that is approved by the US Food and Drug Administration for the treatment of ovarian, breast, non–small cell lung carcinoma, and Kaposi's sarcoma.1 Despite the frequency of cutaneous adverse reactions observed with paclitaxel, only 3 reports of acral erythema24 have been published. Herein, we report a case of keratoderma-like acral erythema presenting in locations atypical for traditional acral erythema, including the dorsal aspects of the hands and feet. Each previously reported case of paclitaxel-induced acral erythema occurred in a similar distribution, suggesting that this acral erythema, while unusual, represents a unique presentation of a common adverse effect of chemotherapy.

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Figure 1. Right lateral foot with mild erythema and a central yellow plaque in a linear pattern.

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Figure 2. Skin punch biopsy specimen from the right foot plaque. Epithelial acanthosis with prominent compact orthokeratotic hyperkeratosis and areas of parakeratosis are seen (hematoxylin-eosin, original magnification ×10).




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