The Cutting Edge: Challenges in Medical and Surgical Therapies |

Successful Treatment of Bullous Pemphigoid With Omalizumab

Vanessa A. London, MD, MS; Gene H. Kim, MD; Janet A. Fairley, MD; David T. Woodley, MD
Arch Dermatol. 2012;148(11):1241-1243. doi:10.1001/archdermatol.2012.1604.
Text Size: A A A
Published online


Bullous pemphigoid (BP) is an acquired, autoimmune, bullous disease that is characterized by autoantibodies against the 230-kDa bullous pemphigoid antigen within basal keratinocytes and the 180-kDa type XVII collagen within the basement membrane zone (BMZ) lying between the epidermis and dermis.1 In addition to skin blisters, patients with BP often experience pruritus and erythematous urticaria-like skin lesions.2 IgG is usually the predominant autoantibody in the plasma and skin of patients with BP.3 Nevertheless, most of these patients also have IgE autoantibodies against type XVII collagen, and these IgE autoantibodies have been shown to be pathogenic.2,46 Herein, we report a case of a woman with pruritic BP and very high levels of IgE and eosinophils who was refractory to standard aggressive immunosuppressive regimens for BP but responded rapidly to systemic omalizumab, a biological agent that binds to and nullifies IgE.

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Graphic Jump Location

Figure. Comparison of right hand prior to treatment. A, Treatment with omalizumab, showing multiple bullae. B, Four weeks after treatment.




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles