Accepted for Publication: August 30, 2012.
Published Online: November 19, 2012. doi:10.1001/jamadermatol.2013.1078
Author Contributions: Drs Paller, Mercy, and Kwasny had full access to all the data in the study. Dr Paller takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Paller. Acquisition of data: Paller, Choon, Cordoro, Girolomoni, Tom, Mahoney, Oostveen, and Seyger. Analysis and interpretation of data: Paller, Mercy, Kwasny, Menter, and Seyger. Drafting of the manuscript: Paller, Mercy, and Kwasny. Critical revision of the manuscript for important intellectual content: Mercy, Choon, Cordoro, Girolomoni, Menter, Tom, Mahoney, Oostveen, and Seyger. Statistical analysis: Kwasny. Obtained funding: Paller. Administrative, technical, and material support: Paller, Mercy, and Menter. Study supervision: Paller, Cordoro, Girolomoni, and Mahoney.
Conflict of Interest Disclosures: During the past 5 years, Dr Paller served as an investigator, without personal compensation, for Amgen-Immunex, Astellas, and Leo Pharma and as a consultant with honorarium for Abbott, Amgen-Immunex, Johnson and Johnson, and Leo Pharma. Dr Seyger received grants from Leo Pharma and Pfizer, served as a consultant for Pfizer and Abbott, gave lectures for Pfizer, and travelled with Abbott, Pfizer, and Leo Pharma to meetings; fees were paid directly to the institution. Dr Choon received honoraria for service on the scientific advisory boards for Janssen-Cilag and Pfizer and as a speaker for Janssen-Cilag and Leo Pharma. Dr Girolomoni has received honoraria from lectures, manuscript preparation, development of educational programs, and/or board membership from Abbott, Celgene, Centocor, Janssen, Merck-Serono, Pfizer, Merck Sharp & Dohme, and Novartis. Dr Menter has received honoraria as a consultant for Abbott, Amgen, Centocor, Eli Lilly, Steifel, and Wyeth; as a speaker for Abbott, Amgen, Centocor, Galderma, and Wyeth; and for providing testimony for Galderma. Dr Tom's salary related to inflammatory skin disease research is supported, in part, by Career Development Award K23AR060274 from the National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases. Dr Mercy's salary was supported, in part, by a fellowship from the National Psoriasis Foundation.
Funding/Support: This study was supported by a grant from the International Psoriasis Council (www.psoriasiscouncil.org), which participated in study design and served as the repository of de-identified information.
Disclaimer: The International Psoriasis Council had no role in the analysis and interpretation of the data or in the preparation, review, or approval of the manuscript.
Additional Contributions: The following dermatologists were principal investigators at their centers and enrolled children in this investigation: Ricardo Romiti, MD (Brazil), Ian Landells, MD (Canada), Claudia de la Cruz, MD (Chile), Serap Utas, MD, and Osman Kose, MD (Turkey), Ruth Murphy, FRCP (United Kingdom), and April Armstrong, MD, Leah Belazarian, MD, Neil Korman, MD, Craig Leonardi, MD, Moise Levy, MD, Fu-Tong Liu, MD, and Karen Wiss, MD (United States). Christy Langan, BS, at the International Psoriasis Council collected de-identified data and provided them for analysis. Latanya Benjamin, MD, Candrice Heath, MD, Sapna Patel Vaghani, MD, Shields Callahan, MD, and Sinae Vogel, MD, assisted with enrolling participants; Anthony Mancini, MD, and Sarah Chamlin, MD, referred patients; Dennis West, PhD, provided daily supervision of research; and Alfred Rademaker, PhD, performed an early statistical assessment of data. Finally, we are grateful to the clinical trials unit staff at the centers worldwide at which patients were enrolled.