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X-ray Therapy of Adult-Onset Xanthogranuloma Ulcerating Tumors in a 79-Year-Old Man: Report of a Case and Comment

Liselotte Brydensholt Halkjær, MD, PhD; Hans Christian Wulf, MD, Professor, DMSci, PharmD
Arch Dermatol. 2012;148(8):968-969. doi:10.1001/archdermatol.2012.193.
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Adult-onset xanthogranuloma (AOX) is a rare, benign, xanthogranulomatous condition that occurs equally among men and women throughout adulthood. The cause and incidence of AOX are unknown. Since 1963, when AOX was first described,1 a few hundred cases have been reported. The disease presents as yellowish-brown skin tumors of varying size that are usually solitary but can be multiple and occur most frequently on the head and neck. Adult-onset xanthogranuloma is without systemic findings. Clinical manifestations of adult xanthogranulomatous diseases occur in several forms, with or without systemic involvement, and are divided into 4 clinical subtypes: AOX, necrobiotic xanthogranuloma, adult periocular xanthogranuloma associated with asthma, and adult-onset xanthogranuloma associated with Erdheim-Chester disease.2,3

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Figure. Our patient is a 79-year-old man with adult-onset xanthogranuloma (AOX) ulcerating tumors on the scalp. A, Before x-ray therapy, AOX is evident on the scalp. B, Follow-up 18 months after x-ray therapy demonstrated no signs of recurrence of AOX.




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