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Eczematous Drug Eruption After Ustekinumab Treatment

Charlotte Pernet, MD; Bernard Guillot, MD, PhD; Didier Bessis, MD
Arch Dermatol. 2012;148(8):959-960. doi:10.1001/archdermatol.2012.586.
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Ustekinumab is a human monoclonal antibody that blocks interleukin (IL)-12 and IL-23, 2 cytokines that play an important role in the pathogenesis of psoriasis.12 It was approved in 2009 for the treatment of adult moderate to severe chronic plaque psoriasis. We report herein the first case to our knowledge of a patient with an eczematous eruption that appeared after the administration of ustekinumab.

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Grahic Jump Location

Figure 1. Eczematous eruption of the trunk (A) and buttocks (B) 3 days after the second injection of ustekinumab.

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Grahic Jump Location

Figure 2. Histological image. Examination reveals spongiosis, crusted parakeratosis, edema, and discrete perivascular lymphocytic infiltrate in the upper dermis (hematoxylin-eosin, original magnification ×100).

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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