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Research Letters | Aug 2012

Topical Aprepitant in Clinical and Experimental Pruritus

Joanna Wallengren, MD, PhD

Arch Dermatol. 2012;148(8):957-959. doi:10.1001/archdermatol.2012.1018.

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Peroral aprepitant is a nonpeptide inhibitor of tachykinin receptor NK1 approved for use as an antiemetic drug for chemotherapy-induced nausea. Duval and Dubertret¹ first reported that peroral aprepitant effectively reduced pruritus in 3 patients with Sézary syndrome. Similar results were obtained later for 6 of 7 patients with erythrodermic cutaneous T-cell lymphoma.² Ständer et al³ reported an open-label study of 20 patients with chronic pruritus treated for a week with peroral aprepitant. It has been suggested that the effects of aprepitant are related to its preventing of mast-cell activation in the skin.⁴ The aim of the present study was to test this hypothesis with topical aprepitant.

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Figure. Individual ratings of pruritus on the aprepitant- vs vehicle-treated sides prior to (A), 30 minutes after (B), and 2 hours after (C) application. VAS indicates visual analog scale score.

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Wallengren J. Topical Aprepitant in Clinical and Experimental Pruritus. Arch Dermatol. 2012;148(8):957-959. doi:10.1001/archdermatol.2012.1018.

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