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Treatment of Severe Cutaneous Small-Vessel Vasculitis With Mycophenolate Mofetil

M. Tye Haeberle, MD; William B. Adams, MD; Jeffrey P. Callen, MD
Arch Dermatol. 2012;148(8):887-888. doi:10.1001/archdermatol.2011.3037.
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Antineutrophilic cytoplasmic antibody (ANCA)-negative, cutaneous, small-vessel vasculitis (CSVV) is a well-described disease with a variety of treatment options. Mycophenolate mofetil (MMF) is an often-used immunosuppressive drug for inflammatory ailments. Herein we describe the first case of ANCA-negative CSVV treated successfully with MMF.

Correspondence: Dr Adams, Division of Dermatology, Department of Medicine, University of Louisville, 310 E Broadway, Ste 2A, Louisville, KY 40202 (will.adams@louisville.edu).

Accepted for Publication: December 1, 2011.

Author Contributions: All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Haeberle, Adams, and Callen. Acquisition of data: Haeberle, Adams, and Callen. Analysis and interpretation of data: Haeberle, Adams, and Callen. Drafting of the manuscript: Haeberle. Critical revision of the manuscript for important intellectual content: Haeberle, Adams, and Callen. Administrative, technical, and material support: Adams and Callen. Study supervision: Adams and Callen.

Financial Disclosure: Dr Callen has received an honorarium for consulting for Glaxo Smith Kline and serves on a safety monitoring committee for Celgene.

Disclaimer: Dr Callen is the associate editor of the Archives of Dermatology. He was not involved in the editorial evaluation or decision to accept this article for publication.

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Figure 1. Purpuric, ulcerated lesions of anterior lower legs.

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Figure 2. Resolution of lesions following 5 months of mycophenolate mofetil therapy.




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