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The Cutting Edge: Challenges in Medical and Surgical Therapies | July 2012

Treatment of Refractory Prurigo Nodularis With Lenalidomide

Holly Kanavy, DO; Jennifer Bahner, MD; Neil J. Korman, MD, PhD

Arch Dermatol. 2012;148(7):794-796. doi:10.1001/archdermatol.2011.2918.

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Prurigo nodularis is an intensely pruritic disorder in which chronic scratching and rubbing lead to the formation of eroded and excoriated skin nodules that may become generalized. Therapy for prurigo nodularis is notoriously difficult, and relief of pruritus and clearing of the skin lesions is exceedingly difficult to achieve.

Correspondence: Holly Kanavy, DO, Department of Dermatology, University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Bldg, Ste 3100, Cleveland, OH 44122 (hollykanavy@yahoo.com).

Accepted for Publication: November 10, 2011.

Author Contributions: Drs Kanavy, Bahner, and Korman had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Kanavy, Bahner, and Korman. Acquisition of data: Kanavy, Bahner, and Korman. Analysis and interpretation of data: Kanavy, Bahner, and Korman. Drafting of the manuscript: Kanavy, Bahner, and Korman. Critical revision of the manuscript for important intellectual content: Kanavy, Bahner, and Korman. Administrative, technical, and material support: Kanavy, Bahner, and Korman.

Financial Disclosure: None reported.

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Figure. After 1 month of treatment with lenalidomide, our patient had near-complete resolution of pruritus, and visible healing of the prurigo nodules had occurred.

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Kanavy H, Bahner J, Korman NJ. Treatment of Refractory Prurigo Nodularis With Lenalidomide. Arch Dermatol. 2012;148(7):794-796. doi:10.1001/archdermatol.2011.2918.

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