We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
The Cutting Edge: Challenges in Medical and Surgical Therapies |

Treatment of Refractory Prurigo Nodularis With Lenalidomide

Holly Kanavy, DO; Jennifer Bahner, MD; Neil J. Korman, MD, PhD
Arch Dermatol. 2012;148(7):794-796. doi:10.1001/archdermatol.2011.2918.
Text Size: A A A
Published online


Prurigo nodularis is an intensely pruritic disorder in which chronic scratching and rubbing lead to the formation of eroded and excoriated skin nodules that may become generalized. Therapy for prurigo nodularis is notoriously difficult, and relief of pruritus and clearing of the skin lesions is exceedingly difficult to achieve.

Correspondence: Holly Kanavy, DO, Department of Dermatology, University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Bldg, Ste 3100, Cleveland, OH 44122 (hollykanavy@yahoo.com).

Accepted for Publication: November 10, 2011.

Author Contributions: Drs Kanavy, Bahner, and Korman had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Kanavy, Bahner, and Korman. Acquisition of data: Kanavy, Bahner, and Korman. Analysis and interpretation of data: Kanavy, Bahner, and Korman. Drafting of the manuscript: Kanavy, Bahner, and Korman. Critical revision of the manuscript for important intellectual content: Kanavy, Bahner, and Korman. Administrative, technical, and material support: Kanavy, Bahner, and Korman.

Financial Disclosure: None reported.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Graphic Jump Location

Figure. After 1 month of treatment with lenalidomide, our patient had near-complete resolution of pruritus, and visible healing of the prurigo nodules had occurred.




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

5 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles