The incidence of cutaneous malignant neoplasms, including BCCs and SCCs, is constantly rising globally. These keratinocytic cancers are the most common cancers in the white population.1 Knowing this, it is no surprise that dermatologists, surgeons, and general practitioners will encounter an increasing number of patients with these tumors. Keratinocytic cancers result from complex interactions between environmental exposure (eg, lifestyle factors), phenotypic characteristics, and genetic predisposition. This systematic review and meta-analysis by Leonardi-Bee et al2 has taken a closer look at smoking as a potential risk factor for BCC and SCC. The most important conclusion is confirmation of an independent association between smoking and the increased likelihood of SCC development by more than 50% (OR, 1.52; 95% CI, 1.15-2.01). This finding was based on pooled data of 6 relatively small studies, of which only 1 had a prospective cohort design. The generalizabilty of the findings is likely to be moderate because the heterogeneity was quite high (I2 = 64%).
Thank you for submitting a comment on this article. It will be reviewed by JAMA Dermatology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
The Rational Clinical Examination
The Rational Clinical Examination
The best background information for diagnosing airflow limitation is exposure to cigarette smoke....
All results at
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.