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Correspondence |

Perinatal Cytomegalovirus-Associated Bullae in an Immunocompetent Infant

Kayo Yasuda, MD; Kazumitsu Sugiura, MD, PhD; Riho Ishikawa, MD; Maho Kihira, MD; Yutaka Negishi, MD, PhD; Hideyuki Iwayama, MD, PhD; Koichi Ito, MD, PhD; Hiroshi Kimura, MD, PhD; Isao Kosugi, MD, PhD; Masashi Akiyama, MD, PhD
Arch Dermatol. 2012;148(6):770-772. doi:10.1001/archdermatol.2011.3258.
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Although perinatal cytomegalovirus (CMV) infection is common, symptomatic CMV infection is a rare complication in immunocompetent infants. We describe herein CMV-associated bullae accompanied by CMV hepatitis in an immunocompetent newborn infant is reported.

Correspondence: Dr Sugiura, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan (kazusugi@med.nagoya-u.ac.jp).

Financial Disclosure: None reported.

Funding/Support: This study was supported in part by Grant -in-Aid for Scientific Research (C) 23591617 from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Dr Sugiura).

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Figure 1. Skin manifestations of the patient. A and B, On the day of admission at patient age 1 month, pustules and erosions with crusts are scattered on the forehead (A) and on the chin and the chest (B). C, After administration of anticytomegalovirus agents, the skin lesions on the chin healed with scarring.

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Figure 2. Histopathologic findings from the bulla on the lower jaw. A, Microblisters (arrows) and reticular degeneration (between triangles) of the epidermis are seen (hematoxylin-eosin, original magnification ×400). B, Perivascular inflammatory cell infiltration and thickening of the blood vessel wall are seen in the superficial dermis (hematoxylin-eosin, original magnification ×400).




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