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Correspondence |

Complete Clearance of Reticular Erythematous Mucinosis With Quinacrine Monotherapy

Laura Susok, MD; Alexander Kreuter, MD
Arch Dermatol. 2012;148(6):768-769. doi:10.1001/archdermatol.2012.53.
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Reticular erythematous mucinosis (REM) syndrome is a rare skin disease that predominantly affects the chest area of middle-aged women.1 The clinical and histopathologic features of REM syndrome suggest a close association with cutaneous lupus erythematosus (CLE). Antimalarial drugs are the first-line systemic treatment for CLE, and many patients with REM also show improvement or clearing of their skin lesions after treatment with antimalarial agents.1,2 However, in a small proportion of patients, conventional antimalarial agents such as chloroquine or hydroxychloroquine might be unsuitable, for example in patients with certain eye diseases. We herein report a case of REM syndrome with a contraindication for conventional antimalarial agents that completely cleared with quinacrine hydrochloride monotherapy.

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Figure. Clinical images of our 42-year-old female patient. A, Reticular erythematous mucinosis at first presentation in our department; symmetrical reticular erythema is present on the central chest area. B, After 3 months of quinacrine hydrochloride monotherapy, all former skin lesions have completely cleared.




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