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Research Letters | June 2012

Induced Lentiginosis With Use of Topical Calcineurin Inhibitors

Leslie Castelo-Soccio, MD, PhD; Dely Di Marcantonio, MD; Puja Shah, MD; Lara Wine Lee, MD, PhD; James R. Treat, MD; Albert C. Yan, MD

Arch Dermatol. 2012;148(6):766-768. doi:10.1001/archdermatol.2012.377.

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Acquired lentiginosis at sites of inflammatory skin disease may occur at the sites where topical tacrolimus or pimecrolimus was applied.¹

Correspondence: Dr Castelo-Soccio, Section of Dermatology, Children's Hospital of Philadelphia, 3550 Market St, Ste 2044, Philadelphia, PA 19104 (castelosocciol@email.chop.edu).

Accepted for Publication: January 27, 2012.

Author Contributions: All authors had full access to all of the data in this observation and take responsibility for the integrity of the data and the accuracy of analysis. Study concept and design: Castelo-Soccio, Shah, and Yan. Acquisition of data: Castelo-Soccio, Di Marcantonio, Shah, Wine Lee, Treat, and Yan. Analysis and interpretation of data: Castelo-Soccio, Di Marcantonio, Shah, Treat, and Yan. Drafting of the manuscript: Castelo-Soccio, Di Marcantonio, Shah, Wine Lee, and Yan. Critical revision of the manuscript for important intellectual content: Castelo-Soccio, Treat, and Yan. Administrative, technical, and material support: Castelo-Soccio, Shah, and Yan. Study supervision: Castelo-Soccio, Treat, and Yan.

Financial Disclosure: None reported.

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Figure 1. Lentigines on the lateral aspect of the dorsal fifth finger of the left hand in the area of chronic atopic dermatitis and long-term topical tacrolimus use.

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Figure 2. Lentigines on the leg at the sites of psoriasis treated with topical tacrolimus.

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Castelo-Soccio L, Di Marcantonio D, Shah P, Lee L, Treat JR, Yan AC. Induced Lentiginosis With Use of Topical Calcineurin Inhibitors. Arch Dermatol. 2012;148(6):766-768. doi:10.1001/archdermatol.2012.377.

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