We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
skINsight |

In Vivo Confocal Microscopic Pattern of Fibroepithelioma of Pinkus

Caterina Longo, MD, PhD; H. Peter Soyer, MD; Patrizia Pepe, MD; Alice Casari, MD; Elisabeth M. T. Wurm, MD; Pascale Guitera, MD; Giovanni Pellacani, MD
Arch Dermatol. 2012;148(4):556. doi:10.1001/archdermatol.2011.945.
Text Size: A A A
Published online


In vivo confocal microscopy was used to visualize 8 cases of fibroepithelioma of Pinkus (FeP). Dermoscopically, there were 5 hypopigmented cases that were characterized by white intersecting lines associated with a vascular pattern and 3 pigmented cases that showed ulceration, patchy hypopigmented and hyperpigmented areas, and dark-brown dots.

In all cases, in vivo confocal microscopy revealed a distinct architecture that was visible at the level of the dermoepidermal junction. The hallmark of FeP was a fenestrated pattern constituted by “holes” that corresponded to the fibrous stroma (Figure, A and B [asterisks]), which was outlined by the tumoral islands or cords (the “frame” of the holes) (Figure, A and B, top [arrows]) that were particularly evident in hypopigmented FeP (Figure, A). Histopathologic examination revealed that both hypopigmented and pigmented lesions were characterized by tumor islands and anastomosing strands of basaloid cells (Figure, A and B, top [arrows]), usually with palisading at the periphery, surrounding a fibrous stroma Figure, A and B, top [asterisks]). In pigmented lesions, a variable amount of plump, bright cells (Figure, C, bottom [arrows]) corresponding to melanin-laden macrophages (Figure, C, top [arrow]) were also present. Histopathologically, all tumors demonstrated strands of basaloid keratinocytes located within an overwhelmingly fibrous stroma.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Graphic Jump Location





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

5 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles