Accepted for Publication: November 22, 2011.
Published Online: January 16, 2012. doi:10.1001/archdermatol.2011.2797
Author Contributions: Drs Apisarnthanarax and Cooper had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Wood, Stevens, Liu, Gerson, Remick, and Cooper. Acquisition of data: Apisarnthanarax, Wood, Liu, Szabo, Gilliam, and Gerson. Analysis and interpretation of data: Apisarnthanarax, Carlson, Chan, Fu, Gilliam, Gerson, and Cooper. Drafting of the manuscript: Apisarnthanarax, Carlson, Gerson, and Cooper. Critical revision of the manuscript for important intellectual content: Apisarnthanarax, Wood, Stevens, Carlson, Chan, Liu, Szabo, Fu, Gerson, Remick, and Cooper. Statistical analysis: Fu. Obtained funding: Apisarnthanarax, Wood, Remick, and Cooper. Administrative, technical, and material support: Gerson and Cooper. Study supervision: Gilliam, Gerson, Remick, and Cooper.
Financial Disclosure: None reported.
Funding/Support: This study was supported in part by Keryx Pharmaceuticals, Inc (who supplied O6-benzylguanine at no cost), the National Institutes of Health (NIH) Phase I Trials of Anticancer Agents, grant U01-CA62502 (to Drs Gerson and Remick), NIH General Clinical Research Center grant M01-RR-00080, NIH KO8AR02063 (to Dr Stevens), NIH R21CA75102-0251 (to Drs Wood and Stevens), NIH Skin Diseases Research Center P30AR39750 (to Dr Cooper), NIH Training Program in Investigative Dermatology T32 AR007569 (to Dr Chan; program director, Dr Cooper), and the Department of Veterans Affairs Medical Research Service (to Drs Wood, Stevens, and Cooper).
Previous Presentations: This work was presented in part at the Society of Investigative Dermatology 63rd Annual Meeting; May 15-18, 2002; Los Angeles, California; at the American Society of Clinical Oncology Annual Meeting; May 31–June 1, 2003; Chicago, Illinois; and at the Society for Investigative Dermatology 68th Annual Meeting; May 9-12, 2007; Los Angeles.
Additional Contributions: Kimberly Sanders, BSN, and Thomas McCormick, PhD, contributed to the design and execution of this clinical trial. Joselin Tacastacas, MD, provided assistance in editing the revised manuscript.