Accepted for Publication: March 2, 2012.
Published Online: April 16, 2012. doi:10.1001/archdermatol.2012.812
Author Contributions: Dr Simpson had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Samrao and Simpson. Acquisition of data: Samrao, Berry, and Simpson. Analysis and interpretation of data: Samrao, Berry, Goreshi, and Simpson. Drafting of the manuscript: Samrao, Berry, Goreshi, and Simpson. Critical revision of the manuscript for important intellectual content: Samrao and Simpson. Statistical analysis: Samrao, Berry, Goreshi, and Simpson. Obtained funding: Simpson. Administrative, technical, and material support: Samrao and Simpson. Study supervision: Simpson.
Financial Disclosure: Dr Simpson has received research grants from Celgene Corp, Abbott Laboratories, Brickell Biotech Inc, Centocor, Galderma, Medicis, Novartis, and Stiefel.
Funding/Support: This study was funded by an investigator-initiated research grant from Celgene Corp. Support was also obtained from the Oregon Clinical and Translational Research Institute grant No. 5 KL2 RR024141-04 from the National Center for Research Resources, a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research.
Role of the Sponsors: The sponsor had no involvement in study design, analysis, or manuscript preparation.
Additional Contributions: Kristina Vartanian, PhD, and Shannon McWeeney, PhD, performed the gene arrays and analyzed the gene expression data. Christine E. Carocci provided editing assistance and Jon M. Hanifin, MD, pioneered the work regarding the role of PDE in AD that inspired the development of this study.