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Research Letters |

Clinical Decision Making Based on Histopathologic Grading and Margin Status of Dysplastic Nevi FREE

Keith L. Duffy, MD; David J. Mann, MD; Vesna Petronic-Rosic, MD; Christopher R. Shea, MD
[+] Author Affiliations

Author Affiliations: Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City (Dr Duffy); and Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois (Drs Mann, Petronic-Rosic, and Shea).


Arch Dermatol. 2012;148(2):259-260. doi:10.1001/archdermatol.2011.2045.
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Published online

The purpose of the present study was to determine how clinicians elect to treat a histologic dysplastic nevus (DN) given a reported grade of the dysplasia and margin involvement on a biopsy report.

An anonymous survey was distributed to the members of the Chicago Dermatologic Society during the annual meeting in March of 2009. Respondents were asked what clinical decisions they would make based on hypothetical pathology reports of varying histopathologic grades of DN with and without margin involvement. For survey purposes, we characterized DN as histopathologically displaying mild, moderate, or severe atypia. We did not specify if the nevi were primarily graded on the architectural or cytologic features. A total of 6 case scenarios were presented to the respondents. The survey questions were presented as follows:

Biopsy report states the patient has a mildly (or moderately/severely) dysplastic nevus with positive (or clear) margins. Elect to: Observe, Re-excise or Other.

A freehand response was allowed for the “Other ” option. Institutional review board approval was waived for this anonymous survey.

Of the 158 surveys distributed, 101 were returned for a 58% response rate. There was no significant difference in the probability of electing to reexcise nevi with mild vs moderate dysplasia in patients with clear margins reported on pathologic evaluation (Figure, A). If the margins were positive, there was a significantly greater probability of electing to reexcise the DN for all grades of dysplasia (Figure, B). The greatest quantitative shift in decision making (from observe to reexcise) as a function of involved margins was seen for DN with moderate dysplasia. Specifically, the decision to reexcise DN with moderate dysplasia inverted from 9% to 81% of respondents.

Place holder to copy figure label and caption
Graphic Jump Location

Figure. Degree of atypia with clear margins (A) and involved margins (B).

This study finds that both grade and margin status are important variables in determining surgical decisions; margin status is most influential when applied to DN of moderate grade. Margin status does not appear to be as critical for clinical decision making of DN with mild or severe dysplasia.

Previous studies,1,2 also using surveys, have attempted to elicit the reexcision rate of DN histologically confirmed, but those studies did not directly address the histologic grade of the lesion or the margin status of the biopsy specimen. The responses from both of those studies indicated that both the margin status and the degree of dysplasia had some role in the decision to reexcise. The present study addresses the effect of both degree of atypia and margin status reported on the clinician's decision to observe or reexcise a DN.

The DN is a controversial subject in dermatology, and although there are no universally accepted criteria for grading DN (or the biologic consequence of these lesions), it remains common clinical practice. In our small sample, 83% of respondents indicated that the dermatopathology reports they receive comment on the grade of a dysplastic nevus.

Our findings are relevant because there is mounting evidence that reexcision of lesions with low-grade atypia (mild and moderate DN) may not be necessary, even when positive margins are found3,4; the recurrence rates of these nevi are low, and there are no reports of subsequent development of melanoma in these lesions. Larger prospective trials are still needed to help define a standard of care with respect to histopathologically proven DN.

Our survey demonstrates the likely clinical decisions given a pathology report defining the degree of histopathologic atypia and margin involvement. It is helpful for dermatopathologists to know the clinical consequences of their pathology report and for other clinicians to see how their colleagues approach these controversial lesions.

Correspondence: Dr Duffy, Department of Dermatology, University of Utah, 30 N 1900 E, 4A330 SOM, Salt Lake City, UT 84132 (keith.duffy@hsc.utah.edu).

Accepted for Publication: September 29, 2011.

Author Contributions: All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Mann. Acquisition of data: Mann. Analysis and interpretation of data: Duffy, Mann, Petronic-Rosic, and Shea. Drafting of the manuscript: Mann. Critical revision of the manuscript for important intellectual content: Duffy, Mann, Petronic-Rosic, and Shea. Administrative, technical, and material support: Mann. Study supervision: Duffy, Petronic-Rosic, and Shea.

Financial Disclosure: None reported.

Funding/Support: This study was supported in part by the Section of Dermatology, Department of Medicine, University of Chicago.

Role of the Sponsors: The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of data; or in the preparation, review, or approval of the manuscript.

Additional Contributions: We are indebted to Yves Lussier for performing statistical analysis on the data.

Fung MA. Terminology and management of dysplastic nevi: responses from 145 dermatologists.  Arch Dermatol. 2003;139(10):1374-1375
PubMed   |  Link to Article
Tripp JM, Kopf AW, Marghoob AA, Bart RS. Management of dysplastic nevi: a survey of fellows of the American Academy of Dermatology.  J Am Acad Dermatol. 2002;46(5):674-682
PubMed   |  Link to Article
Goodson AG, Florell SR, Boucher KM, Grossman D. Low rates of clinical recurrence after biopsy of benign to moderately dysplastic melanocytic nevi.  J Am Acad Dermatol. 2010;62(4):591-596
PubMed   |  Link to Article
Kmetz EC, Sanders H, Fisher G, Lang PG, Maize JC Sr. The role of observation in the management of atypical nevi.  South Med J. 2009;102(1):45-48
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure. Degree of atypia with clear margins (A) and involved margins (B).

Tables

References

Fung MA. Terminology and management of dysplastic nevi: responses from 145 dermatologists.  Arch Dermatol. 2003;139(10):1374-1375
PubMed   |  Link to Article
Tripp JM, Kopf AW, Marghoob AA, Bart RS. Management of dysplastic nevi: a survey of fellows of the American Academy of Dermatology.  J Am Acad Dermatol. 2002;46(5):674-682
PubMed   |  Link to Article
Goodson AG, Florell SR, Boucher KM, Grossman D. Low rates of clinical recurrence after biopsy of benign to moderately dysplastic melanocytic nevi.  J Am Acad Dermatol. 2010;62(4):591-596
PubMed   |  Link to Article
Kmetz EC, Sanders H, Fisher G, Lang PG, Maize JC Sr. The role of observation in the management of atypical nevi.  South Med J. 2009;102(1):45-48
PubMed   |  Link to Article

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