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Correspondence |

A Novel Application of Topical Rapamycin Formulation, an Inhibitor of mTOR, for Patients With Hypomelanotic Macules in Tuberous Sclerosis Complex

Mari Wataya-Kaneda, MD, PhD; Mari Tanaka, MD; Ayumi Nakamura, BPharm; Shoji Matsumoto, PhD; Ichiro Katayama, MD, PhD
Arch Dermatol. 2012;148(1):138-139. doi:10.1001/archderm.148.1.138.
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Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by systemic hamartomas. Two genes, TSCI and TSCII, which encode hamartin and tuberin, are responsible for TSC. The complex of hamartin and tuberin inhibits the mammalian target of rapamycin (mTOR),1 which has numerous functions in the regulation of protein synthesis and cell growth. The constitutive activation of mTOR is associated with abnormal cellular proliferation, which causes TSC-related hamartomas.

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Figure. Clinical images. Hypomelanotic macules (white arrows) before treatment (A and C) disappeared after treatment with rapamycin gel, 0.2% (B) and ointment (D). Both angiofibromas (A) and red plaque (C) (black arrows) were reduced by the rapamycin treatments (B and D).

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