0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Interferon- γ Release Assay

Leonard M. Milstone, MD; Byron H. Waksman, MD
Arch Dermatol. 2012;148(1):133-134. doi:10.1001/archdermatol.2011.2077.
Text Size: A A A
Published online

Extract

Readers of a recent article published in the Archives about the usefulness of an interferon- γ release assay in diagnosing erythema induratum1 might like to put that work in historical and technical perspective. Many years ago, a medical student (L.M.M.), wondering why lymphocytes infiltrated virus-infected tissues, teamed up with an immunologist (B.H.W.) working in the emerging field of lymphokines. They hypothesized that sensitized lymphocytes challenged by a specific antigen might release an inhibitor of viral replication. Since tuberculin reactivity was a standard (and nonviral) manifestation of delayed-type hypersensitivity, they took lymphocytes from mice immunized with PPD (purified protein derivative, used in tuberculosis skin testing), challenged them in vitro with PPD, and found that those lymphocytes secreted an inhibitor of vesicular stomatitis virus growth.2 That secreted inhibitor eventually became known as interferon- γ, and the basics of that original test have been recapitulated in several interferon- γ release assays for tuberculosis.3

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();