Infantile hemangiomas (IHs) are common vascular tumors of infancy. Although spontaneous involution is common, ulceration, scarring, recurrent bleeding, and obstruction of vital structures can complicate untreated IHs. Corticosteroids were the mainstay of treatment of IHs until recently, when the effectiveness of propranolol has been established. In this multicenter retrospective chart review, Price et al demonstrate that propranolol therapy was more clinically effective and cost-effective than oral corticosteroids in treating IHs. It also resulted in fewer surgical interventions and demonstrated better tolerance, suggesting that propranolol should be considered a first-line agent in treating IHs.