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Correspondence |

Successful Long-term Use of Intravenous Immunoglobulin to Treat Livedoid Vasculopathy Associated With Plasminogen Activator Inhibitor-1 Promoter Homozygosity

Papapit Tuchinda, MD; Antonella Tammaro, MD; Anthony A. Gaspari, MD
Arch Dermatol. 2011;147(10):1224-1225. doi:10.1001/archdermatol.2011.274.
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We previously reported the case of a 33-year-old woman who was diagnosed as having livedoid vasculopathy (LV) associated with plasminogen activator inhibitor-1 (PAI-1) promoter homozygosity (4G/4G).1 In patients with homozygosity for the 4G allele, high levels of PAI-1 may be associated with increased risk of venous thromboembolism, coronary disease, and poor outcome of stroke.1 This patient was successfully treated with infusions of tissue plasminogen activator (tPA) (10 mg/d for 2 weeks) after failed treatments with anti-inflammatory and antiplatelet therapies.

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